HitPredict

Interactor 1: UB2D2 (P62837)
Ubiquitin-conjugating enzyme E2 D2 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D2) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D2) (Ubiquitin carrier protein D2) (Ubiquitin-conjugating enzyme E2(17)KB 2) (Ubiquitin-conjugating enzyme E2-17 kDa 2) (Ubiquitin-protein ligase D2) (p53-regulated ubiquitin-conjugating enzyme 1)
Gene: UBE2D2

Interactor 2: M3K1 (Q13233)
Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (EC 2.3.2.27)
Gene: MAP3K1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	19690564
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 147 Hs			1 1512
+	Hs
		1028455 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		M3K1_HUMAN (1-1512): 0: 1994: 100.00
+	Hs
		849319 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		M3K1_HUMAN (1-1512): 0: 1994: 100.00
+	Hs
		895785 UB2D3_HUMAN (1-147): 1.54e-81: 238: 97.28		M3K1_HUMAN (1-1512): 0: 1994: 100.00
+	Hs
		851810 UB2E1_HUMAN (4-146): 8.81e-73: 217: 65.73		M3K1_HUMAN (1-1512): 0: 1994: 100.00
+	Mm
		101509 UBE2N_MOUSE (4-147): 7.67e-69: 206: 47.22		F8VQ72_MOUSE (1-1512): 0: 1937: 88.41
+	Zm
		13349 A0A1D6FSE0_MAIZE (1-147): 4.86e-83: 242: 79.59		A0A1Q0ZG94_MAIZE (840-1510): 2.6e-121: 413: 18.54
+	Zm
		35309 A0A1D6LKH6_MAIZE (2-144): 2.27e-70: 211: 46.85		A0A1Q0ZG94_MAIZE (840-1510): 2.6e-121: 413: 18.54
+	Zm
		8408 A0A1D6ENM7_MAIZE (1-147): 4.27e-82: 241: 77.55		Q6RXY1_MAIZE (1229-1509): 8.04e-118: 382: 27.31
+	Dm
		715095 UBE2N_DROME (4-147): 8.8e-45: 145: 49.31		AKT1_DROME (970-1510): 8.64e-126: 407: 17.03
+	Hs
		625230 UBE2A_HUMAN (2-144): 1.41e-70: 210: 39.16		CDK2_HUMAN (1243-1509): 1.1e-104: 337: 25.85
+	Hs
		625285 UBE2N_HUMAN (4-147): 7.67e-69: 206: 47.22		CDK2_HUMAN (1243-1509): 1.1e-104: 337: 25.85
+	Zm
		15814 A0A1D6LKH6_MAIZE (2-144): 2.27e-70: 211: 46.85		A0A1D6GGI2_MAIZE (1242-1511): 2.1e-42: 169: 35.87