HitPredict

Interactor 1: UB2D2 (P62837)
Ubiquitin-conjugating enzyme E2 D2 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D2) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D2) (Ubiquitin carrier protein D2) (Ubiquitin-conjugating enzyme E2(17)KB 2) (Ubiquitin-conjugating enzyme E2-17 kDa 2) (Ubiquitin-protein ligase D2) (p53-regulated ubiquitin-conjugating enzyme 1)
Gene: UBE2D2

Interactor 2: SQSTM (Q13501)
Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62)
Gene: SQSTM1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.644

Property	Details
Experiments	28322253, 31241013
Identification Methods	two hybrid, pull down, affinity chromatography technology, enzymatic study
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process GO:0031625 - ubiquitin protein ligase binding GO:0070062 - extracellular exosome
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 147 Hs			1 440
+	Hs
		895789 UB2D3_HUMAN (1-147): 1.54e-81: 238: 97.28		SQSTM_HUMAN (1-440): 0: 760: 100.00
+	Hs
		1206094 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		MIB1_HUMAN (105-233): 3.47e-43: 164: 25.19
+	Hs
		849363 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		MIB1_HUMAN (105-233): 3.47e-43: 164: 25.19
+	Hs
		919776 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		MIB1_HUMAN (105-233): 3.47e-43: 164: 25.19
+	Hs
		895841 UB2D3_HUMAN (1-147): 1.54e-81: 238: 97.28		MIB1_HUMAN (105-233): 3.47e-43: 164: 25.19
+	Hs
		896486 UBE2N_HUMAN (4-147): 7.67e-69: 206: 47.22		MIB1_HUMAN (105-233): 3.47e-43: 164: 25.19
+	Hs
		849396 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		MIB2_HUMAN (106-264): 3.55e-23: 104: 26.09
+	Hs
		919813 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		MIB2_HUMAN (106-264): 3.55e-23: 104: 26.09
+	Hs
		319766 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		HERC2_HUMAN (120-197): 2.6e-12: 71.3: 32.50
+	Hs
		319786 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		HERC2_HUMAN (120-197): 2.6e-12: 71.3: 32.50
+	Hs
		896510 UBE2N_HUMAN (4-147): 7.67e-69: 206: 47.22		MIB2_HUMAN (106-264): 3.55e-23: 104: 26.09
+	Hs
		319780 UB2D3_HUMAN (1-147): 1.54e-81: 238: 97.28		HERC2_HUMAN (120-197): 2.6e-12: 71.3: 32.50
+	Hs
		919728 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		NBR1_HUMAN (80-184): 5.95e-10: 63.6: 24.78
+	Hs
		895795 UB2D3_HUMAN (1-147): 1.54e-81: 238: 97.28		NBR1_HUMAN (80-184): 5.95e-10: 63.6: 24.78
+	Hs
		319781 UBE2N_HUMAN (4-147): 7.67e-69: 206: 47.22		HERC2_HUMAN (120-197): 2.6e-12: 71.3: 32.50