HitPredict

Interactor 1: UB2D2 (P62837)
Ubiquitin-conjugating enzyme E2 D2 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D2) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D2) (Ubiquitin carrier protein D2) (Ubiquitin-conjugating enzyme E2(17)KB 2) (Ubiquitin-conjugating enzyme E2-17 kDa 2) (Ubiquitin-protein ligase D2) (p53-regulated ubiquitin-conjugating enzyme 1)
Gene: UBE2D2

Interactor 2: HECD3 (Q5T447)
E3 ubiquitin-protein ligase HECTD3 (EC 2.3.2.26) (HECT domain-containing protein 3) (HECT-type E3 ubiquitin transferase HECTD3)
Gene: HECTD3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.845

Property	Details
Experiments	29643511, 33607208, 35918322
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	HECT~UQ_con
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 147 Hs			1 861
+	Hs
		1294888 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		ITCH_HUMAN (318-855): 0: 545: 17.83
+	Hs
		808052 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		NEDD4_HUMAN (322-853): 5.8e-176: 545: 18.46
+	Hs
		808078 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		NEDD4_HUMAN (322-853): 5.8e-176: 545: 18.46
+	Hs
		919827 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		ITCH_HUMAN (318-855): 0: 545: 17.83
+	Hs
		919867 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		SMUF2_HUMAN (336-855): 3.41e-177: 531: 20.32
+	Hs
		125808 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		WWP2_HUMAN (321-855): 1.45e-172: 523: 17.74
+	Hs
		919834 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		NED4L_HUMAN (374-853): 1.61e-171: 524: 19.11
+	Hs
		125262 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		WWP2_HUMAN (321-855): 1.45e-172: 523: 17.74
+	Hs
		125335 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		WWP2_HUMAN (321-855): 1.45e-172: 523: 17.74
+	Hs
		919860 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		WWP1_HUMAN (250-855): 1.18e-171: 522: 16.67
+	Hs
		919869 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		SMUF1_HUMAN (336-855): 2.1e-167: 506: 17.88
+	Hs
		919765 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		HUWE1_HUMAN (329-854): 6.82e-152: 496: 19.78
+	Hs
		919889 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		HECW2_HUMAN (336-855): 4.75e-146: 471: 20.34
+	Hs
		919762 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		HECW1_HUMAN (364-855): 4.15e-145: 469: 19.05
+	Hs
		919782 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		HACE1_HUMAN (338-857): 5.82e-149: 463: 18.98
+	Hs
		919733 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		HERC1_HUMAN (517-855): 3.98e-53: 204: 36.72
+	Hs
		319766 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		HERC2_HUMAN (237-372): 5.72e-44: 175: 35.77
+	Hs
		319786 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		HERC2_HUMAN (237-372): 5.72e-44: 175: 35.77
+	Hs
		101688 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		F8VWT9_HUMAN (531-847): 2.23e-20: 99.8: 25.91
+	Hs
		919732 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		UBE3C_HUMAN (495-845): 2.66e-20: 99: 27.64