HitPredict

Interactor 1: UB2D2 (P62837)
Ubiquitin-conjugating enzyme E2 D2 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D2) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D2) (Ubiquitin carrier protein D2) (Ubiquitin-conjugating enzyme E2(17)KB 2) (Ubiquitin-conjugating enzyme E2-17 kDa 2) (Ubiquitin-protein ligase D2) (p53-regulated ubiquitin-conjugating enzyme 1)
Gene: UBE2D2

Interactor 2: DTX2 (Q86UW9)
Probable E3 ubiquitin-protein ligase DTX2 (EC 2.3.2.27) (Protein deltex-2) (Deltex2) (hDTX2) (RING finger protein 58) (RING-type E3 ubiquitin transferase DTX2)
Gene: DTX2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.849

Property	Details
Experiments	32296183, 32937373, unassigned1304
Identification Methods	two hybrid, pull down, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4
Common GO terms	GO:0005654 - nucleoplasm GO:0016567 - protein ubiquitination GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 147 Hs			1 622
+	Hs
		1200380 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		DTX2_HUMAN (1-622): 0: 572: 100.00
+	Hs
		849356 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		DTX2_HUMAN (1-622): 0: 572: 100.00
+	Hs
		895835 UB2D3_HUMAN (1-147): 1.54e-81: 238: 97.28		DTX2_HUMAN (1-622): 0: 572: 100.00
+	Hs
		1205017 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		DTX1_HUMAN (17-616): 5.87e-168: 494: 45.85
+	Hs
		849361 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		DTX1_HUMAN (17-616): 5.87e-168: 494: 45.85
+	Hs
		919774 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		DTX1_HUMAN (17-616): 5.87e-168: 494: 45.85
+	Hs
		895839 UB2D3_HUMAN (1-147): 1.54e-81: 238: 97.28		DTX1_HUMAN (17-616): 5.87e-168: 494: 45.85
+	Hs
		851838 UB2E1_HUMAN (4-146): 8.81e-73: 217: 65.73		DTX1_HUMAN (17-616): 5.87e-168: 494: 45.85
+	Hs
		1254722 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		DTX3L_HUMAN (340-614): 3.96e-77: 261: 35.94
+	Hs
		849380 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		DTX3L_HUMAN (340-614): 3.96e-77: 261: 35.94
+	Hs
		919797 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		DTX3L_HUMAN (340-614): 3.96e-77: 261: 35.94
+	Hs
		895856 UB2D3_HUMAN (1-147): 1.54e-81: 238: 97.28		DTX3L_HUMAN (340-614): 3.96e-77: 261: 35.94
+	Hs
		1254709 UB2E2_HUMAN (4-146): 5.85e-75: 223: 65.73		DTX3L_HUMAN (340-614): 3.96e-77: 261: 35.94
+	Hs
		1254705 UB2E3_HUMAN (4-146): 3.05e-74: 221: 66.43		DTX3L_HUMAN (340-614): 3.96e-77: 261: 35.94
+	Hs
		1238409 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		DTX3_HUMAN (439-617): 4.6e-65: 219: 43.65
+	Hs
		849372 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		DTX3_HUMAN (439-617): 4.6e-65: 219: 43.65
+	Hs
		919787 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		DTX3_HUMAN (439-617): 4.6e-65: 219: 43.65
+	Hs
		895846 UB2D3_HUMAN (1-147): 1.54e-81: 238: 97.28		DTX3_HUMAN (439-617): 4.6e-65: 219: 43.65
+	Hs
		1238398 UB2E2_HUMAN (4-146): 5.85e-75: 223: 65.73		DTX3_HUMAN (439-617): 4.6e-65: 219: 43.65
+	Hs
		1238392 UB2E3_HUMAN (4-146): 3.05e-74: 221: 66.43		DTX3_HUMAN (439-617): 4.6e-65: 219: 43.65