HitPredict

Interactor 1: UB2D2 (P62837)
Ubiquitin-conjugating enzyme E2 D2 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D2) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D2) (Ubiquitin carrier protein D2) (Ubiquitin-conjugating enzyme E2(17)KB 2) (Ubiquitin-conjugating enzyme E2-17 kDa 2) (Ubiquitin-protein ligase D2) (p53-regulated ubiquitin-conjugating enzyme 1)
Gene: UBE2D2

Interactor 2: TRI50 (Q86XT4)
E3 ubiquitin-protein ligase TRIM50 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM50) (Tripartite motif-containing protein 50)
Gene: TRIM50

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.845

Property	Details
Experiments	21143188, 32296183, unassigned1304
Identification Methods	two hybrid, two hybrid array, validated two hybrid, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_UBOX
Common GO terms	GO:0005829 - cytosol GO:0016567 - protein ubiquitination GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 147 Hs			1 487
+	Hs
		584923 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		RO52_HUMAN (1-473): 6.68e-148: 433: 26.72
+	Hs
		1336390 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		TRI39_HUMAN (7-474): 9.71e-142: 418: 27.09
+	Hs
		1204911 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		TRI50_HUMAN (1-487): 5.07e-137: 405: 100.00
+	Hs
		537142 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		TRI27_HUMAN (1-475): 2.7e-134: 399: 27.11
+	Hs
		536779 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		TRI27_HUMAN (1-475): 2.7e-134: 399: 27.11
+	Hs
		919822 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		TRI11_HUMAN (1-482): 8.18e-131: 389: 26.84
+	Mm
		919925 UB2D2_MOUSE (1-147): 9.5e-83: 241: 100.00		TRI17_MOUSE (1-463): 4.71e-122: 366: 24.53
+	Hs
		135045 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		TRI38_HUMAN (1-474): 4.59e-120: 361: 24.95
+	Hs
		135019 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		TRI38_HUMAN (1-474): 4.59e-120: 361: 24.95
+	Hs
		1318719 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		TRIM5_HUMAN (1-475): 2.45e-116: 353: 25.00
+	Hs
		919852 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		TRIM7_HUMAN (11-457): 2.1e-116: 353: 28.72
+	Hs
		1377469 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		TRI17_HUMAN (1-463): 4.08e-114: 346: 23.69
+	Hs
		1313765 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		TRI62_HUMAN (9-470): 4.7e-113: 343: 27.97
+	Hs
		919841 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		TRI62_HUMAN (9-470): 4.7e-113: 343: 27.97
+	Hs
		1354526 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		TRI10_HUMAN (1-462): 2.58e-111: 339: 25.00
+	Hs
		1285831 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		TRI43_HUMAN (10-457): 2.23e-107: 328: 19.12
+	Hs
		919816 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		TRI43_HUMAN (10-457): 2.23e-107: 328: 19.12
+	Hs
		1357712 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		TRI35_HUMAN (3-473): 6.13e-102: 316: 25.72
+	Hs
		919846 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		TRI34_HUMAN (1-475): 8.23e-103: 317: 23.81
+	Hs
		919800 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		TRI41_HUMAN (1-44): 3.64e-10: 64.1: 31.25