HitPredict

Interactor 1: UB2D2 (P62837)
Ubiquitin-conjugating enzyme E2 D2 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D2) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D2) (Ubiquitin carrier protein D2) (Ubiquitin-conjugating enzyme E2(17)KB 2) (Ubiquitin-conjugating enzyme E2-17 kDa 2) (Ubiquitin-protein ligase D2) (p53-regulated ubiquitin-conjugating enzyme 1)
Gene: UBE2D2

Interactor 2: PJA1 (Q8NG27)
E3 ubiquitin-protein ligase Praja-1 (Praja1) (EC 2.3.2.27) (RING finger protein 70) (RING-type E3 ubiquitin transferase Praja-1)
Gene: PJA1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.865

Property	Details
Experiments	12036302, 21461837, 36074076
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_2
Common GO terms	GO:0016567 - protein ubiquitination GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 147 Hs			1 643
+	Hs
		196372 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		PJA2_HUMAN (1-642): 1.14e-129: 399: 44.94
+	Hs
		196294 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		PJA2_HUMAN (1-642): 1.14e-129: 399: 44.94
+	Hs
		865028 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		TTC3_HUMAN (29-635): 4.22e-87: 299: 12.34
+	Hs
		1346940 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		RNF12_HUMAN (1-641): 4.33e-52: 191: 12.42
+	Hs
		919877 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		RNF12_HUMAN (1-641): 4.33e-52: 191: 12.42
+	Hs
		1169203 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		RN111_HUMAN (33-643): 6.96e-48: 183: 13.06
+	Hs
		919758 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		RN111_HUMAN (33-643): 6.96e-48: 183: 13.06
+	Zm
		74334 B4FC97_MAIZE (1-147): 3e-83: 242: 79.59		B6U926_MAIZE (392-640): 9.62e-39: 148: 21.83
+	Zm
		79637 B6SZE0_MAIZE (1-147): 3.82e-83: 242: 79.59		B6U926_MAIZE (392-640): 9.62e-39: 148: 21.83
+	Hs
		282607 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		RNF8_HUMAN (383-639): 1.07e-34: 139: 16.85
+	Hs
		1377467 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		RN115_HUMAN (432-639): 6.28e-33: 130: 21.88
+	Hs
		1242076 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		ZNRF1_HUMAN (383-633): 8.23e-33: 128: 14.68
+	Hs
		919790 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		ZNRF1_HUMAN (383-633): 8.23e-33: 128: 14.68
+	Hs
		1356934 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		RN150_HUMAN (523-643): 1.36e-29: 123: 23.39
+	Hs
		1313520 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		RN126_HUMAN (545-639): 9.16e-30: 121: 40.00
+	Hs
		919840 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		RN126_HUMAN (545-639): 9.16e-30: 121: 40.00
+	Hs
		1349753 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		RN181_HUMAN (566-640): 6.22e-29: 114: 38.67
+	Hs
		919885 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		RN181_HUMAN (566-640): 6.22e-29: 114: 38.67
+	At
		715117 UBC8_ARATH (1-147): 8.9e-83: 241: 80.27		ATL78_ARATH (484-637): 1.25e-27: 113: 25.16
+	At
		715128 UBC8_ARATH (1-147): 8.9e-83: 241: 80.27		CIP8_ARATH (546-639): 1.88e-24: 106: 32.98