HitPredict

Interactor 1: UB2D2 (P62837)
Ubiquitin-conjugating enzyme E2 D2 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D2) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D2) (Ubiquitin carrier protein D2) (Ubiquitin-conjugating enzyme E2(17)KB 2) (Ubiquitin-conjugating enzyme E2-17 kDa 2) (Ubiquitin-protein ligase D2) (p53-regulated ubiquitin-conjugating enzyme 1)
Gene: UBE2D2

Interactor 2: ZNRF2 (Q8NHG8)
E3 ubiquitin-protein ligase ZNRF2 (EC 2.3.2.27) (Protein Ells2) (RING finger protein 202) (RING-type E3 ubiquitin transferase ZNRF2) (Zinc/RING finger protein 2)
Gene: ZNRF2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	32265276, 19690564
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UQ_con~zf-RING_2
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0032991 - protein-containing complex GO:0061630 - ubiquitin protein ligase activity GO:0070936 - protein K48-linked ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 147 Hs			1 242
+	Hs
		1242076 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		ZNRF1_HUMAN (1-242): 4.77e-113: 325: 43.32
+	Hs
		849373 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		ZNRF1_HUMAN (1-242): 4.77e-113: 325: 43.32
+	Hs
		919790 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		ZNRF1_HUMAN (1-242): 4.77e-113: 325: 43.32
+	Hs
		895849 UB2D3_HUMAN (1-147): 1.54e-81: 238: 97.28		ZNRF1_HUMAN (1-242): 4.77e-113: 325: 43.32
+	Hs
		1242075 UB2E2_HUMAN (4-146): 5.85e-75: 223: 65.73		ZNRF1_HUMAN (1-242): 4.77e-113: 325: 43.32
+	Hs
		1242072 UB2E3_HUMAN (4-146): 3.05e-74: 221: 66.43		ZNRF1_HUMAN (1-242): 4.77e-113: 325: 43.32
+	Hs
		851849 UB2E1_HUMAN (4-146): 8.81e-73: 217: 65.73		ZNRF1_HUMAN (1-242): 4.77e-113: 325: 43.32
+	Hs
		1245518 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		ZNRF2_HUMAN (1-242): 7.65e-101: 294: 100.00
+	Hs
		849375 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		ZNRF2_HUMAN (1-242): 7.65e-101: 294: 100.00
+	Hs
		895853 UB2D3_HUMAN (1-147): 1.54e-81: 238: 97.28		ZNRF2_HUMAN (1-242): 7.65e-101: 294: 100.00
+	Hs
		896495 UBE2N_HUMAN (4-147): 7.67e-69: 206: 47.22		ZNRF1_HUMAN (1-242): 4.77e-113: 325: 43.32
+	Hs
		1243628 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		Q8NEX1_HUMAN (64-242): 1.78e-96: 281: 93.86
+	Hs
		849374 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		Q8NEX1_HUMAN (64-242): 1.78e-96: 281: 93.86
+	Hs
		919791 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		Q8NEX1_HUMAN (64-242): 1.78e-96: 281: 93.86
+	Hs
		895850 UB2D3_HUMAN (1-147): 1.54e-81: 238: 97.28		Q8NEX1_HUMAN (64-242): 1.78e-96: 281: 93.86
+	Hs
		1245511 UB2E2_HUMAN (4-146): 5.85e-75: 223: 65.73		ZNRF2_HUMAN (1-242): 7.65e-101: 294: 100.00
+	Hs
		1245509 UB2E3_HUMAN (4-146): 3.05e-74: 221: 66.43		ZNRF2_HUMAN (1-242): 7.65e-101: 294: 100.00
+	Hs
		851850 UB2E1_HUMAN (4-146): 8.81e-73: 217: 65.73		ZNRF2_HUMAN (1-242): 7.65e-101: 294: 100.00
+	Hs
		896498 UBE2N_HUMAN (4-147): 7.67e-69: 206: 47.22		ZNRF2_HUMAN (1-242): 7.65e-101: 294: 100.00
+	Hs
		896497 UBE2N_HUMAN (4-147): 7.67e-69: 206: 47.22		Q8NEX1_HUMAN (64-242): 1.78e-96: 281: 93.86