HitPredict

Interactor 1: UB2D2 (P62837)
Ubiquitin-conjugating enzyme E2 D2 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D2) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D2) (Ubiquitin carrier protein D2) (Ubiquitin-conjugating enzyme E2(17)KB 2) (Ubiquitin-conjugating enzyme E2-17 kDa 2) (Ubiquitin-protein ligase D2) (p53-regulated ubiquitin-conjugating enzyme 1)
Gene: UBE2D2

Interactor 2: COP1 (Q8NHY2)
E3 ubiquitin-protein ligase COP1 (EC 2.3.2.27) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1) (RING finger and WD repeat domain protein 2) (RING finger protein 200) (RING-type E3 ubiquitin transferase RFWD2)
Gene: COP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.888

Property	Details
Experiments	36650277, 16931761, 15103385, 21625211
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UQ_con~WD40, UQ_con~zf-C3HC4_2
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0016567 - protein ubiquitination GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 147 Hs			1 731
+	Hs
		849377 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		COP1_HUMAN (1-731): 0: 540: 100.00
+	Hs
		895854 UB2D3_HUMAN (1-147): 1.54e-81: 238: 97.28		COP1_HUMAN (1-731): 0: 540: 100.00
+	Hs
		1246146 UB2E2_HUMAN (4-146): 5.85e-75: 223: 65.73		COP1_HUMAN (1-731): 0: 540: 100.00
+	Hs
		851851 UB2E1_HUMAN (4-146): 8.81e-73: 217: 65.73		COP1_HUMAN (1-731): 0: 540: 100.00
+	Hs
		896507 UBE2N_HUMAN (4-147): 7.67e-69: 206: 47.22		FBXW7_HUMAN (452-730): 4.46e-69: 242: 17.15
+	Hs
		1163056 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		TRAF7_HUMAN (450-730): 4.97e-50: 188: 15.19
+	Hs
		849344 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		TRAF7_HUMAN (450-730): 4.97e-50: 188: 15.19
+	Hs
		919755 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		TRAF7_HUMAN (450-730): 4.97e-50: 188: 15.19
+	At
		794493 COP10_ARATH (4-146): 4.37e-58: 180: 56.64		COP1_ARATH (512-730): 3.95e-30: 128: 17.67
+	Hs
		828991 UBE2A_HUMAN (2-144): 1.41e-70: 210: 39.16		RBBP4_HUMAN (512-702): 3.22e-20: 96: 14.49