HitPredict

Interactor 1: UB2D2 (P62837)
Ubiquitin-conjugating enzyme E2 D2 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D2) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D2) (Ubiquitin carrier protein D2) (Ubiquitin-conjugating enzyme E2(17)KB 2) (Ubiquitin-conjugating enzyme E2-17 kDa 2) (Ubiquitin-protein ligase D2) (p53-regulated ubiquitin-conjugating enzyme 1)
Gene: UBE2D2

Interactor 2: UBA3 (Q8TBC4)
NEDD8-activating enzyme E1 catalytic subunit (EC 6.2.1.64) (NEDD8-activating enzyme E1C) (Ubiquitin-activating enzyme E1C) (Ubiquitin-like modifier-activating enzyme 3) (Ubiquitin-activating enzyme 3)
Gene: UBA3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	29643511
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	E2_bind~UQ_con, ThiF~UQ_con
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005829 - cytosol GO:0032991 - protein-containing complex GO:0036211 - protein modification process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 147 Hs			1 463
+	Hs
		1282360 UB2E3_HUMAN (4-146): 3.05e-74: 221: 66.43		SAE2_HUMAN (57-421): 9.94e-90: 287: 28.75
+	Hs
		607190 UB2D4_HUMAN (1-147): 2.21e-83: 243: 93.20		UBA1_HUMAN (46-363): 1.38e-28: 121: 15.25
+	Hs
		48104 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		UBA6_HUMAN (16-242): 1.06e-28: 121: 17.67
+	Hs
		48107 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		UBA6_HUMAN (16-242): 1.06e-28: 121: 17.67
+	Hs
		607026 UB2D1_HUMAN (1-147): 7.06e-83: 241: 89.12		UBA1_HUMAN (46-363): 1.38e-28: 121: 15.25
+	Hs
		607050 UB2D2_HUMAN (1-147): 9.5e-83: 241: 100.00		UBA1_HUMAN (46-363): 1.38e-28: 121: 15.25
+	Hs
		48106 UB2D3_HUMAN (1-147): 1.54e-81: 238: 97.28		UBA6_HUMAN (16-242): 1.06e-28: 121: 17.67
+	Hs
		607039 UB2D3_HUMAN (1-147): 1.54e-81: 238: 97.28		UBA1_HUMAN (46-363): 1.38e-28: 121: 15.25
+	Hs
		607136 UB2E2_HUMAN (4-146): 5.85e-75: 223: 65.73		UBA1_HUMAN (46-363): 1.38e-28: 121: 15.25
+	Sc
		549788 UBC4_YEAST (3-147): 1.04e-79: 233: 80.00		UBA1_YEAST (35-212): 5.24e-25: 110: 22.35
+	Hs
		607129 UB2E3_HUMAN (4-146): 3.05e-74: 221: 66.43		UBA1_HUMAN (46-363): 1.38e-28: 121: 15.25
+	Hs
		782203 UB2E1_HUMAN (4-146): 8.81e-73: 217: 65.73		UBA7_HUMAN (40-212): 7.63e-29: 122: 21.39
+	Hs
		607028 UB2E1_HUMAN (4-146): 8.81e-73: 217: 65.73		UBA1_HUMAN (46-363): 1.38e-28: 121: 15.25
+	Hs
		607023 UBE2A_HUMAN (2-144): 1.41e-70: 210: 39.16		UBA1_HUMAN (46-363): 1.38e-28: 121: 15.25
+	Sp
		293848 UBC4_SCHPO (1-147): 1.21e-80: 236: 84.35		UBA1_SCHPO (48-189): 8.73e-20: 94.5: 19.72
+	Hs
		607054 UBE2B_HUMAN (2-144): 5.71e-70: 209: 37.76		UBA1_HUMAN (46-363): 1.38e-28: 121: 15.25
+	Hs
		607042 UBE2N_HUMAN (4-147): 7.67e-69: 206: 47.22		UBA1_HUMAN (46-363): 1.38e-28: 121: 15.25
+	Sp
		251976 UBC1_SCHPO (4-146): 6.92e-45: 147: 45.83		UBA1_SCHPO (48-189): 8.73e-20: 94.5: 19.72
+	Sp
		293851 UBC14_SCHPO (8-146): 5.28e-43: 140: 47.14		UBA1_SCHPO (48-189): 8.73e-20: 94.5: 19.72
+	Dm
		715098 UBE2N_DROME (4-147): 8.8e-45: 145: 49.31		Q8T0L3_DROME (46-374): 5.82e-18: 89.1: 14.68