HitPredict

Interactor 1: GBB1 (P62873)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Transducin beta chain 1)
Gene: GNB1

Interactor 2: PHLP (Q13371)
Phosducin-like protein (PHLP)
Gene: PDCL

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	1.00	0.948

Property	Details
Experiments	33961781, 34342229, 35271311, 19376773, 25675501, 15889144
Identification Methods	affinity chromatography technology, x-ray crystallography, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	Phosducin~WD40
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 340 Hs			1 301
+	Hs
		921553 GBB2_HUMAN (1-340): 1e-105: 314: 90.29		PHLP_HUMAN (1-301): 1.36e-118: 344: 100.00
+	Hs
		1032876 GBB4_HUMAN (1-340): 6.23e-105: 312: 90.88		PHLP_HUMAN (1-301): 1.36e-118: 344: 100.00
+	Hs
		560877 GBB3_HUMAN (1-340): 1.83e-104: 311: 83.24		PHLP_HUMAN (1-301): 1.36e-118: 344: 100.00
+	Dm
		640826 GBB1_DROME (1-340): 1.54e-103: 309: 83.53		PHLP_DROME (1-277): 9.39e-89: 267: 44.41
+	Bt
		586005 GBB1_BOVIN (1-340): 7.02e-105: 312: 100.00		PHOS_BOVIN (51-291): 6.2e-75: 231: 46.89
+	Hs
		921720 GBB2_HUMAN (1-340): 1e-105: 314: 90.29		PDCL3_HUMAN (74-301): 5.67e-67: 210: 26.78
+	Ce
		567435 GBB1_CAEEL (1-340): 7.67e-107: 317: 85.88		Q9U1X7_CAEEL (4-269): 1.69e-59: 192: 27.14
+	Hs
		154679 GNB5_HUMAN (129-340): 1.35e-45: 161: 21.46		PHLP_HUMAN (1-301): 1.36e-118: 344: 100.00
+	Hs
		147235 GBB2_HUMAN (1-340): 1e-105: 314: 90.29		TXND9_HUMAN (104-287): 1.42e-50: 168: 18.85
+	Hs
		1032854 POC1A_HUMAN (10-125): 4.11e-27: 112: 17.24		PHLP_HUMAN (1-301): 1.36e-118: 344: 100.00
+	Sc
		579444 GBB_YEAST (2-340): 1.33e-76: 243: 36.53		PLP1_YEAST (97-301): 2.51e-45: 154: 20.36
+	Sc
		579445 GBB_YEAST (2-340): 1.33e-76: 243: 36.53		PLP2_YEAST (71-301): 1.5e-43: 152: 15.66
+	Hs
		1240457 POC1A_HUMAN (10-125): 4.11e-27: 112: 17.24		PDCL3_HUMAN (74-301): 5.67e-67: 210: 26.78
+	Hs
		147268 POC1A_HUMAN (10-125): 4.11e-27: 112: 17.24		TXND9_HUMAN (104-287): 1.42e-50: 168: 18.85