HitPredict

Interactor 1: GBB1 (P62873)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Transducin beta chain 1)
Gene: GNB1

Interactor 2: CDKL2 (Q92772)
Cyclin-dependent kinase-like 2 (EC 2.7.11.22) (Protein kinase p56 KKIAMRE) (Serine/threonine-protein kinase KKIAMRE)
Gene: CDKL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0007165 - signal transduction
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 340 Hs			1 493
+	Hs
		921672 GBB2_HUMAN (1-340): 1e-105: 314: 90.29		CDKL2_HUMAN (1-493): 8.56e-169: 487: 100.00
+	Hs
		625324 GBB2_HUMAN (1-340): 1e-105: 314: 90.29		CDK2_HUMAN (1-293): 1.93e-156: 448: 40.14
+	Hs
		921638 GBB2_HUMAN (1-340): 1e-105: 314: 90.29		CDKL3_HUMAN (1-459): 2.55e-138: 412: 42.59
+	Hs
		921006 GBB1_HUMAN (1-340): 7.02e-105: 312: 100.00		CDKL3_HUMAN (1-459): 2.55e-138: 412: 42.59
+	Hs
		625202 LIS1_HUMAN (259-340): 1.35e-18: 87.8: 23.17		CDK2_HUMAN (1-293): 1.93e-156: 448: 40.14
+	Hs
		414806 LIS1_HUMAN (259-340): 1.35e-18: 87.8: 23.17		CDK1_HUMAN (1-292): 1.25e-139: 405: 39.12
+	Sc
		565470 NLE1_YEAST (2-297): 8.98e-80: 253: 18.55		PHO85_YEAST (3-287): 7.59e-58: 195: 35.41