HitPredict

Interactor 1: GBB1 (P62873)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Transducin beta chain 1)
Gene: GNB1

Interactor 2: GBG8 (Q9UK08)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 (Gamma-9)
Gene: GNG8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.799

Property	Details
Experiments	33961781, 12782285
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	G-gamma~WD40
Common GO terms	GO:0003924 - GTPase activity GO:0005834 - heterotrimeric G-protein complex GO:0005886 - plasma membrane GO:0007186 - G protein-coupled receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 340 Hs			1 70
+	Hs
		887097 GBB2_HUMAN (1-340): 1e-105: 314: 90.29		GBG2_HUMAN (2-70): 8.61e-27: 94: 71.01
+	Hs
		921516 GBB2_HUMAN (1-340): 1e-105: 314: 90.29		GBG3_HUMAN (3-70): 4.08e-26: 92.4: 57.35
+	Bt
		920925 GBB1_BOVIN (1-340): 7.02e-105: 312: 100.00		GBG2_BOVIN (2-70): 8.61e-27: 94: 71.01
+	Mm
		921088 GBB1_MOUSE (1-340): 7.02e-105: 312: 100.00		GBG2_MOUSE (2-70): 8.61e-27: 94: 71.01
+	Hs
		921771 GBB2_HUMAN (1-340): 1e-105: 314: 90.29		GBG8_HUMAN (1-70): 9.17e-26: 91.3: 100.00
+	Hs
		837673 GBB2_HUMAN (1-340): 1e-105: 314: 90.29		GBG4_HUMAN (2-70): 1.82e-25: 90.9: 60.87
+	Hs
		837672 GBB1_HUMAN (1-340): 7.02e-105: 312: 100.00		GBG4_HUMAN (2-70): 1.82e-25: 90.9: 60.87
+	Hs
		229238 GBB2_HUMAN (1-340): 1e-105: 314: 90.29		GBG7_HUMAN (3-70): 1.04e-23: 86.2: 52.94
+	Hs
		921761 GBB2_HUMAN (1-340): 1e-105: 314: 90.29		GBG12_HUMAN (2-70): 4.08e-23: 84.7: 49.28
+	Hs
		229237 GBB1_HUMAN (1-340): 7.02e-105: 312: 100.00		GBG7_HUMAN (3-70): 1.04e-23: 86.2: 52.94
+	Hs
		837687 GBB2_HUMAN (1-340): 1e-105: 314: 90.29		GBG10_HUMAN (3-70): 1.97e-21: 80.5: 48.53
+	Hs
		837686 GBB1_HUMAN (1-340): 7.02e-105: 312: 100.00		GBG10_HUMAN (3-70): 1.97e-21: 80.5: 48.53
+	Hs
		921517 GBB2_HUMAN (1-340): 1e-105: 314: 90.29		GBG5_HUMAN (3-70): 1.81e-20: 77.8: 44.12
+	Hs
		921515 GBB2_HUMAN (1-340): 1e-105: 314: 90.29		GBG1_HUMAN (4-69): 4.75e-20: 77: 33.33
+	Hs
		929139 Q6FHM2_HUMAN (1-340): 1e-105: 314: 90.29		GBG1_HUMAN (4-69): 4.75e-20: 77: 33.33
+	Bt
		362122 GBB1_BOVIN (1-340): 7.02e-105: 312: 100.00		GBG1_BOVIN (4-69): 2.18e-20: 77.8: 33.33
+	Hs
		150115 GBB2_HUMAN (1-340): 1e-105: 314: 90.29		GBGT2_HUMAN (1-69): 1.52e-18: 73.2: 31.88
+	Hs
		150114 GBB1_HUMAN (1-340): 7.02e-105: 312: 100.00		GBGT2_HUMAN (1-69): 1.52e-18: 73.2: 31.88
+	Ce
		567432 GBB1_CAEEL (1-340): 7.67e-107: 317: 85.88		GBG_CAEEL (8-70): 3.02e-14: 62: 39.68
+	Ce
		105444 GBB1_CAEEL (1-340): 7.67e-107: 317: 85.88		G5ECT6_CAEEL (6-70): 1.14e-13: 60.4: 33.85