HitPredict

Interactor 1: RBX1 (P62877)
E3 ubiquitin-protein ligase RBX1 (EC 2.3.2.27) (EC 2.3.2.32) (E3 ubiquitin-protein transferase RBX1) (Protein ZYP) (RING finger protein 75) (RING-box protein 1) (Rbx1) (Regulator of cullins 1) (ROC1) [Cleaved into: E3 ubiquitin-protein ligase RBX1, N-terminally processed (E3 ubiquitin-protein transferase RBX1, N-terminally processed)]
Gene: RBX1

Interactor 2: CUL7 (Q14999)
Cullin-7 (CUL-7)
Gene: CUL7

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.94 1.00 0.970

The method score is based on:

Property Details
Experiments 12481031, 33961781, 33504946, 16547496, 16142236, 25752541, 31343991, 23045529, 12904573
Identification Methods affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Cullin~zf-rbx1
Common GO terms GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0016567 - protein ubiquitination
GO:0031467 - Cul7-RING ubiquitin ligase complex
and 1 others

more...
Homologous interactions 6

Homologous interactions

Color coding for hit scores

1 108
Hs

1 1698
+ Mm
+ Hs
+ Mm
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+ Sc

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024