HitPredict

Interactor 1: RBX1 (P62877)
E3 ubiquitin-protein ligase RBX1 (EC 2.3.2.27) (EC 2.3.2.32) (E3 ubiquitin-protein transferase RBX1) (Protein ZYP) (RING finger protein 75) (RING-box protein 1) (Rbx1) (Regulator of cullins 1) (ROC1) [Cleaved into: E3 ubiquitin-protein ligase RBX1, N-terminally processed (E3 ubiquitin-protein transferase RBX1, N-terminally processed)]
Gene: RBX1

Interactor 2: FBX42 (Q6P3S6)
F-box only protein 42 (Just one F-box and Kelch domain-containing protein)
Gene: FBXO42

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	33961781, 33504946, 36129980, 19509332
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0019005 - SCF ubiquitin ligase complex
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 108 Hs			1 717
+	Hs
		299513 RBX1_HUMAN (1-108): 5.69e-51: 157: 100.00		KLH18_HUMAN (2-238): 8.3e-37: 147: 11.81
+	Hs
		921305 RBX1_HUMAN (1-108): 5.69e-51: 157: 100.00		KLD10_HUMAN (170-471): 1.7e-35: 142: 16.83
+	At
		1275961 RBX1A_ARATH (17-108): 2.43e-43: 139: 93.48		ADO1_ARATH (48-319): 3.07e-40: 158: 21.99
+	Hs
		921260 RBX1_HUMAN (1-108): 5.69e-51: 157: 100.00		KEAP1_HUMAN (4-181): 1.55e-32: 135: 12.92
+	Hs
		921454 RBX1_HUMAN (1-108): 5.69e-51: 157: 100.00		KLHL9_HUMAN (243-522): 3.14e-31: 131: 10.67
+	Hs
		921405 RBX1_HUMAN (1-108): 5.69e-51: 157: 100.00		KLDC3_HUMAN (2-216): 8.72e-32: 129: 17.62
+	Hs
		921456 RBX1_HUMAN (1-108): 5.69e-51: 157: 100.00		KLH13_HUMAN (243-522): 1.94e-30: 129: 10.67
+	Hs
		921481 RBX1_HUMAN (1-108): 5.69e-51: 157: 100.00		KLDC2_HUMAN (19-213): 5.56e-20: 95: 17.41