HitPredict

Interactor 1: RBX1 (P62877)
E3 ubiquitin-protein ligase RBX1 (EC 2.3.2.27) (EC 2.3.2.32) (E3 ubiquitin-protein transferase RBX1) (Protein ZYP) (RING finger protein 75) (RING-box protein 1) (Rbx1) (Regulator of cullins 1) (ROC1) [Cleaved into: E3 ubiquitin-protein ligase RBX1, N-terminally processed (E3 ubiquitin-protein transferase RBX1, N-terminally processed)]
Gene: RBX1

Interactor 2: FBX17 (Q96EF6)
F-box only protein 17 (F-box only protein 26)
Gene: FBXO17

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	33961781, 33504946, 18203720
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019005 - SCF ubiquitin ligase complex GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 108 Hs			1 278
+	Hs
		921440 RBX1_HUMAN (1-108): 5.69e-51: 157: 100.00		FBX6_HUMAN (17-278): 2.63e-121: 350: 33.83
+	Hs
		921351 RBX1_HUMAN (1-108): 5.69e-51: 157: 100.00		FBX27_HUMAN (31-278): 2.03e-117: 339: 58.07
+	Hs
		921430 RBX1_HUMAN (1-108): 5.69e-51: 157: 100.00		FBX44_HUMAN (18-277): 1.27e-114: 331: 33.71
+	Hs
		921466 RBX1_HUMAN (1-108): 5.69e-51: 157: 100.00		FBX2_HUMAN (28-275): 2.19e-106: 312: 36.47
+	Hs
		921313 RBX1_HUMAN (1-108): 5.69e-51: 157: 100.00		FBX50_HUMAN (110-276): 7.92e-52: 172: 30.59