HitPredict

Interactor 1: RBX1 (P62877)
E3 ubiquitin-protein ligase RBX1 (EC 2.3.2.27) (EC 2.3.2.32) (E3 ubiquitin-protein transferase RBX1) (Protein ZYP) (RING finger protein 75) (RING-box protein 1) (Rbx1) (Regulator of cullins 1) (ROC1) [Cleaved into: E3 ubiquitin-protein ligase RBX1, N-terminally processed (E3 ubiquitin-protein transferase RBX1, N-terminally processed)]
Gene: RBX1

Interactor 2: FXL15 (Q9H469)
F-box/LRR-repeat protein 15 (F-box only protein 37)
Gene: FBXL15

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	33961781, 21572392
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016567 - protein ubiquitination GO:0019005 - SCF ubiquitin ligase complex GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 108 Hs			1 300
+	Hs
		921245 RBX1_HUMAN (1-108): 5.69e-51: 157: 100.00		SKP2_HUMAN (5-293): 1.21e-37: 139: 18.63
+	Hs
		921337 RBX1_HUMAN (1-108): 5.69e-51: 157: 100.00		FXL14_HUMAN (29-276): 1.48e-30: 120: 23.55
+	Hs
		921472 RBX1_HUMAN (1-108): 5.69e-51: 157: 100.00		FBXL2_HUMAN (5-249): 1.36e-30: 120: 22.05
+	Hs
		921461 RBX1_HUMAN (1-108): 5.69e-51: 157: 100.00		FXL17_HUMAN (143-299): 4.94e-19: 89.2: 20.25
+	Hs
		1031293 RBX2_HUMAN (20-107): 8.91e-31: 107: 50.00		SKP2_HUMAN (5-293): 1.21e-37: 139: 18.63
+	Hs
		921349 RBX1_HUMAN (1-108): 5.69e-51: 157: 100.00		KDM2B_HUMAN (1-166): 8.52e-12: 67.7: 16.83
+	Sc
		624320 RBX1_YEAST (17-107): 8.73e-38: 125: 64.84		GRR1_YEAST (168-275): 1.57e-10: 63.9: 22.02