HitPredict

Interactor 1: RBX1 (P62878)
E3 ubiquitin-protein ligase RBX1 (EC 2.3.2.27) (EC 2.3.2.32) (E3 ubiquitin-protein transferase RBX1) (RING finger protein 75) (RING-box protein 1) (Rbx1) [Cleaved into: E3 ubiquitin-protein ligase RBX1, N-terminally processed]
Gene: RBX1

Interactor 2: CUL7 (Q8VE73)
Cullin-7 (CUL-7) (p185) (p193)
Gene: CUL7

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.776

Property	Details
Experiments	24793696, 16880526
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Cullin~zf-rbx1
Common GO terms	GO:0006511 - ubiquitin-dependent protein catabolic process GO:0016567 - protein ubiquitination GO:0031467 - Cul7-RING ubiquitin ligase complex GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 108 Mm			1 1689
+	Hs
		921266 RBX1_HUMAN (1-108): 5.69e-51: 157: 100.00		CUL7_HUMAN (1-1689): 0: 2792: 76.39
+	Hs
		921334 RBX1_HUMAN (1-108): 5.69e-51: 157: 100.00		CUL9_HUMAN (1-601): 0: 890: 47.45
+	Mm
		921510 RBX1_MOUSE (1-108): 5.69e-51: 157: 100.00		S4R1Y1_MOUSE (1-669): 0: 872: 43.42
+	Hs
		1219383 RBX2_HUMAN (20-107): 8.91e-31: 107: 50.00		CUL9_HUMAN (1-601): 0: 890: 47.45
+	Hs
		1348498 APC11_HUMAN (20-105): 8.33e-28: 98.6: 37.08		APC10_HUMAN (809-948): 1.07e-53: 187: 20.00
+	Sc
		858872 APC11_YEAST (20-105): 5.39e-26: 96.3: 26.17		APC10_YEAST (803-952): 5.47e-45: 165: 17.68