HitPredict

Interactor 1: PPIA (P62937)
Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) [Cleaved into: Peptidyl-prolyl cis-trans isomerase A, N-terminally processed]
Gene: PPIA

Interactor 2: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	35563538, 21145461, 37207277
Identification Methods	affinity chromatography technology, tandem affinity purification, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0070062 - extracellular exosome
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 165 Hs			1 768
+	Hs
		203519 PPIH_HUMAN (2-164): 1.38e-84: 247: 53.85		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		834741 RBP2_HUMAN (3-164): 1.87e-73: 240: 66.67		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		923677 PPIA_HUMAN (1-165): 2.77e-91: 264: 100.00		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		923674 PPIA_HUMAN (1-165): 2.77e-91: 264: 100.00		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		834739 RBP2_HUMAN (3-164): 1.87e-73: 240: 66.67		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		923675 PPIA_HUMAN (1-165): 2.77e-91: 264: 100.00		CUL2_HUMAN (30-768): 0: 672: 26.17
+	Hs
		834740 RBP2_HUMAN (3-164): 1.87e-73: 240: 66.67		CUL2_HUMAN (30-768): 0: 672: 26.17