HitPredict

Interactor 1: FKB1A (P62942)
Peptidyl-prolyl cis-trans isomerase FKBP1A (PPIase FKBP1A) (EC 5.2.1.8) (12 kDa FK506-binding protein) (12 kDa FKBP) (FKBP-12) (Calstabin-1) (FK506-binding protein 1A) (FKBP-1A) (Immunophilin FKBP12) (Rotamase)
Gene: FKBP1A

Interactor 2: ITPR1 (Q14643)
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 (IP3 receptor isoform 1) (IP3R 1) (InsP3R1) (Inositol 1,4,5 trisphosphate receptor) (Inositol 1,4,5-trisphosphate receptor type 1) (Type 1 inositol 1,4,5-trisphosphate receptor) (Type 1 InsP3 receptor)
Gene: ITPR1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	1.00	0.757

Property	Details
Experiments	16278292, 9346894
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	FKBP_C~RYDR_ITPR
Common GO terms	GO:0016020 - membrane GO:0016529 - sarcoplasmic reticulum
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 108 Hs			1 2758
+	Hs
		923827 FKB1A_HUMAN (1-108): 2e-54: 166: 100.00		RYR3_HUMAN (1606-2268): 1.15e-104: 380: 19.64
+	Hs
		932945 FKB1B_HUMAN (1-108): 2.61e-52: 161: 83.33		RYR3_HUMAN (1606-2268): 1.15e-104: 380: 19.64
+	Hs
		923834 FKB1A_HUMAN (1-108): 2e-54: 166: 100.00		RYR2_HUMAN (1804-2263): 1.54e-83: 310: 21.14
+	Hs
		932950 FKB1B_HUMAN (1-108): 2.61e-52: 161: 83.33		RYR2_HUMAN (1804-2263): 1.54e-83: 310: 21.14
+	Mm
		93493 FKB1B_MOUSE (1-108): 3.25e-51: 158: 82.41		RYR2_MOUSE (1804-2263): 7.13e-84: 311: 21.14
+	Mm
		93348 FKB1A_MOUSE (1-108): 3.43e-54: 166: 97.22		RYR1_MOUSE (1804-2263): 4.73e-71: 269: 19.49
+	Oc
		514745 FKB1A_RABIT (1-108): 2e-54: 166: 100.00		RYR1_RABIT (1804-2263): 6.51e-71: 268: 19.49
+	Hs
		601658 FKB1A_HUMAN (1-108): 2e-54: 166: 100.00		RYR1_HUMAN (1804-2263): 1.02e-70: 268: 19.49
+	Rn
		94032 FKB1A_RAT (1-108): 5.55e-54: 165: 97.22		RYR1_RAT (1804-2263): 5.43e-67: 256: 19.12