HitPredict

Interactor 1: AP2B1 (P62944)
AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit)
Gene: AP2B1

Interactor 2: Q5JC29 (Q5JC29)
Epidermal growth factor receptor pathway substrate 15 isoform B
Gene: Eps15

Species: Rattus norvegicus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	16903783
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0030122 - AP-2 adaptor complex GO:0045202 - synapse GO:0048268 - clathrin coat assembly GO:0098794 - postsynapse GO:0098884 - postsynaptic neurotransmitter receptor internalization and 1 others more... GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 937 Rn			1 792
+	Hs
		787890 AP2B1_HUMAN (1-937): 0: 926: 100.00		EPS15_HUMAN (1-788): 4.17e-139: 435: 88.34
+	Mm
		788007 AP2B1_MOUSE (1-937): 0: 926: 99.89		EPS15_MOUSE (1-777): 4.77e-126: 400: 94.34
+	Hs
		787903 AP1B1_HUMAN (1-937): 0: 888: 82.72		EPS15_HUMAN (1-788): 4.17e-139: 435: 88.34
+	Hs
		926038 AP2B1_HUMAN (1-937): 0: 926: 100.00		EP15R_HUMAN (1-790): 2.69e-95: 318: 41.01
+	Rn
		923861 AP2B1_RAT (1-937): 0: 926: 100.00		ITSN1_RAT (9-776): 1.45e-80: 285: 16.87
+	Hs
		1014098 AP1B1_HUMAN (1-937): 0: 888: 82.72		EP15R_HUMAN (1-790): 2.69e-95: 318: 41.01
+	Hs
		926031 AP2B1_HUMAN (1-937): 0: 926: 100.00		ITSN2_HUMAN (6-783): 1.02e-70: 255: 15.39
+	Hs
		1014096 AP1B1_HUMAN (1-937): 0: 888: 82.72		ITSN2_HUMAN (6-783): 1.02e-70: 255: 15.39
+	Hs
		321504 AP2A1_HUMAN (11-932): 0: 634: 16.97		EPS15_HUMAN (1-788): 4.17e-139: 435: 88.34
+	Hs
		925876 AP2B1_HUMAN (1-937): 0: 926: 100.00		ITSN1_HUMAN (2-530): 3.39e-32: 137: 13.75
+	Rn
		88764 D3ZUY8_RAT (11-932): 0: 625: 17.14		Q5JC29_RAT (1-792): 1.51e-137: 427: 100.00
+	Hs
		925970 AP2B1_HUMAN (1-937): 0: 926: 100.00		REPS1_HUMAN (2-493): 7.62e-28: 122: 12.28
+	Hs
		1014017 AP1B1_HUMAN (1-937): 0: 888: 82.72		ITSN1_HUMAN (2-530): 3.39e-32: 137: 13.75
+	Hs
		1014062 AP1B1_HUMAN (1-937): 0: 888: 82.72		REPS1_HUMAN (2-493): 7.62e-28: 122: 12.28
+	Hs
		321661 AP2A1_HUMAN (11-932): 0: 634: 16.97		EP15R_HUMAN (1-790): 2.69e-95: 318: 41.01
+	Ce
		1341625 Q9N4F3_CAEEL (1-935): 0: 770: 62.11		Q9U2T9_CAEEL (6-767): 5.71e-42: 167: 14.23
+	Hs
		321552 AP2A1_HUMAN (11-932): 0: 634: 16.97		ITSN1_HUMAN (2-530): 3.39e-32: 137: 13.75
+	Hs
		321615 AP2A1_HUMAN (11-932): 0: 634: 16.97		REPS1_HUMAN (2-493): 7.62e-28: 122: 12.28
+	Hs
		321600 AP2A1_HUMAN (11-932): 0: 634: 16.97		REPS2_HUMAN (39-606): 2.04e-20: 98.2: 14.33
+	Hs
		321640 AP2A1_HUMAN (11-932): 0: 634: 16.97		EHD1_HUMAN (17-102): 1.92e-16: 85.4: 33.72