HitPredict

Interactor 1: RS27A (P62979)
Ubiquitin-ribosomal protein eS31 fusion protein (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31 (40S ribosomal protein S27a)]
Gene: RPS27A

Interactor 2: WWP1 (Q9H0M0)
NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 2.3.2.26) (Atrophin-1-interacting protein 5) (AIP5) (HECT-type E3 ubiquitin transferase WWP1) (TGIF-interacting ubiquitin ligase 1) (Tiul1) (WW domain-containing protein 1)
Gene: WWP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	29635000
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HECT~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016567 - protein ubiquitination and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 156 Hs			1 922
+	Hs
		125347 RS27A_HUMAN (1-156): 3.55e-76: 225: 100.00		WWP2_HUMAN (1-922): 0: 841: 57.84
+	Hs
		475140 UBB_HUMAN (1-76): 6.65e-36: 125: 100.00		ITCH_HUMAN (1-922): 0: 884: 57.14
+	Rn
		1140970 UBC_RAT (1-119): 1.57e-36: 134: 68.29		Q5YB86_RAT (11-922): 0: 854: 57.63
+	Hs
		125112 UBB_HUMAN (1-76): 6.65e-36: 125: 100.00		WWP2_HUMAN (1-922): 0: 841: 57.84
+	Hs
		474953 UBB_HUMAN (1-76): 6.65e-36: 125: 100.00		NEDD4_HUMAN (84-919): 0: 723: 33.52
+	Mm
		924239 RS27A_MOUSE (1-156): 8.08e-76: 224: 99.36		HUWE1_MOUSE (130-921): 2.15e-172: 558: 24.29
+	Hs
		924336 RL40_HUMAN (1-125): 5.33e-44: 142: 64.80		HUWE1_HUMAN (130-921): 1.4e-172: 559: 24.48
+	Sc
		408448 RS31_YEAST (1-151): 4.55e-61: 187: 82.78		TOM1_YEAST (439-921): 2.08e-156: 512: 31.81
+	Mm
		476858 UBC_MOUSE (1-119): 1.07e-36: 135: 67.48		HUWE1_MOUSE (130-921): 2.15e-172: 558: 24.29
+	Hs
		475080 UBB_HUMAN (1-76): 6.65e-36: 125: 100.00		HUWE1_HUMAN (130-921): 1.4e-172: 559: 24.48
+	Dm
		89880 RL40_DROME (1-125): 1.01e-43: 142: 64.80		D5SHR3_DROME (502-922): 3.31e-173: 511: 44.03
+	At
		1091758 UBQ3_ARATH (1-77): 2.19e-35: 126: 94.81		UPL1_ARATH (453-920): 3.91e-161: 525: 35.09
+	Sc
		477647 RL40A_YEAST (1-125): 2.07e-42: 139: 64.00		TOM1_YEAST (439-921): 2.08e-156: 512: 31.81
+	At
		1091762 UBQ3_ARATH (1-77): 2.19e-35: 126: 94.81		UPL2_ARATH (430-920): 1.83e-159: 520: 33.14
+	Dm
		1376481 Q9W418_DROME (1-77): 1.7e-34: 127: 100.00		Q9W325_DROME (502-922): 6.36e-171: 505: 43.79
+	Sc
		408371 RS31_YEAST (1-151): 4.55e-61: 187: 82.78		RSP5_YEAST (16-424): 6.88e-44: 173: 20.05
+	Sp
		145416 RS27A_SCHPO (1-151): 1.04e-57: 178: 81.46		PUB3_SCHPO (13-424): 2.07e-43: 171: 17.73
+	Sp
		145417 RS27B_SCHPO (1-151): 8.29e-58: 178: 81.46		PUB3_SCHPO (13-424): 2.07e-43: 171: 17.73
+	Sp
		145418 RL402_SCHPO (1-125): 7.03e-41: 135: 63.20		PUB3_SCHPO (13-424): 2.07e-43: 171: 17.73
+	Hs
		924414 RL40_HUMAN (1-125): 5.33e-44: 142: 64.80		SMUF2_HUMAN (7-381): 2.95e-31: 133: 16.24