HitPredict

Interactor 1: RL40 (P62987)
Ubiquitin-ribosomal protein eL40 fusion protein (CEP52) (Ubiquitin A-52 residue ribosomal protein fusion product 1) [Cleaved into: Ubiquitin; Large ribosomal subunit protein eL40 (60S ribosomal protein L40)]
Gene: UBA52

Interactor 2: KMT2A (Q03164)
Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]
Gene: KMT2A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34349018
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0036211 - protein modification process
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 128 Hs			1 3969
+	Hs
		923965 RS27A_HUMAN (1-77): 2.11e-38: 128: 98.70		KMT2A_HUMAN (1-3969): 0: 3187: 100.00
+	Hs
		475038 UBB_HUMAN (1-76): 1.52e-33: 118: 100.00		EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54
+	Mm
		1111861 Q3TH47_MOUSE (1-78): 8.15e-33: 117: 97.44		Q6AXH7_MOUSE (3450-3951): 9.61e-104: 354: 18.18
+	At
		1114632 RL40B_ARATH (1-128): 1.3e-54: 168: 92.19		SUVR4_ARATH (3744-3965): 1.52e-63: 228: 21.81
+	Hs
		331777 RS27A_HUMAN (1-77): 2.11e-38: 128: 98.70		NSD2_HUMAN (3752-3968): 7.27e-60: 231: 27.23
+	Dm
		1214032 Q9W418_DROME (1-77): 1.45e-41: 145: 98.70		LUBEL_DROME (185-1127): 1.73e-16: 89.7: 11.69