HitPredict

Interactor 1: RL40 (P62987)
Ubiquitin-ribosomal protein eL40 fusion protein (CEP52) (Ubiquitin A-52 residue ribosomal protein fusion product 1) [Cleaved into: Ubiquitin; Large ribosomal subunit protein eL40 (60S ribosomal protein L40)]
Gene: UBA52

Interactor 2: ZNRF4 (Q8WWF5)
E3 ubiquitin-protein ligase ZNRF4 (EC 2.3.2.27) (Nixin) (RING finger protein 204) (RING-type E3 ubiquitin transferase ZNRF4) (Zinc/RING finger protein 4)
Gene: ZNRF4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	ubiquitin~zf-RING_2
Common GO terms	GO:0005737 - cytoplasm GO:0005783 - endoplasmic reticulum GO:0005789 - endoplasmic reticulum membrane GO:0016567 - protein ubiquitination
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 128 Hs			1 429
+	Hs
		924340 RL40_HUMAN (1-128): 1.05e-56: 174: 100.00		GOLI_HUMAN (118-429): 2.7e-64: 214: 19.58
+	Hs
		924057 RS27A_HUMAN (1-77): 2.11e-38: 128: 98.70		GOLI_HUMAN (118-429): 2.7e-64: 214: 19.58
+	Hs
		475090 UBB_HUMAN (1-76): 1.52e-33: 118: 100.00		GOLI_HUMAN (118-429): 2.7e-64: 214: 19.58
+	Hs
		475059 UBB_HUMAN (1-76): 1.52e-33: 118: 100.00		RNF43_HUMAN (116-427): 1.04e-45: 170: 17.12
+	At
		1091813 UBQ3_ARATH (1-78): 1.98e-32: 117: 93.59		RNG1L_ARATH (281-394): 1.32e-25: 108: 24.59
+	At
		1092053 UBQ3_ARATH (1-78): 1.98e-32: 117: 93.59		Q9FM98_ARATH (281-365): 5.9e-20: 93: 28.24
+	At
		477669 UBQ11_ARATH (1-76): 4.36e-33: 117: 96.05		Q9FM98_ARATH (281-365): 5.9e-20: 93: 28.24