HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.91 1.00 0.957

The method score is based on:

Property Details
Experiments 24189400, 31980649, 7716522, 32062451, 19380743, 12577067, 22726438, 22536782
Identification Methods affinity chromatography technology, x-ray crystallography, pull down, microscale thermophoresis, light scattering
Interaction Type physical association, association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains SH2~SH2, SH2~SH3_1, SH3_1~SH3_1
Common GO terms GO:0001784 - phosphotyrosine residue binding
GO:0003723 - RNA binding
GO:0005068 - transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005091 - guanyl-nucleotide exchange factor adaptor activity
GO:0005154 - epidermal growth factor receptor binding
and 38 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 217
Hs

1 217
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Mm
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024