HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: ACTH (P63267)
Actin, gamma-enteric smooth muscle (EC 3.6.4.-) (Alpha-actin-3) (Gamma-2-actin) (Smooth muscle gamma-actin) [Cleaved into: Actin, gamma-enteric smooth muscle, intermediate form]
Gene: ACTG2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	12577067
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 217 Hs			1 376
+	Hs
		891671 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		ACTB_HUMAN (1-376): 0: 601: 93.35
+	Hs
		924453 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		ACTG_HUMAN (3-376): 0: 601: 94.39
+	Hs
		924456 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		ACTC_HUMAN (2-376): 0: 598: 98.67
+	Hs
		548718 VAV_HUMAN (2-60): 8.95e-15: 74.6: 42.37		ACTBL_HUMAN (1-376): 0: 713: 87.77
+	Hs
		337422 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		ACTS_HUMAN (2-376): 0: 598: 98.13
+	Hs
		454818 FGR_HUMAN (120-215): 6.83e-13: 68.8: 22.45		ACTB_HUMAN (1-376): 0: 601: 93.35
+	Hs
		548675 VAV_HUMAN (2-60): 8.95e-15: 74.6: 42.37		ACTA_HUMAN (1-376): 0: 595: 99.20
+	Hs
		442804 HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39		ACTB_HUMAN (1-376): 0: 601: 93.35
+	Hs
		522893 SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58		ACTS_HUMAN (2-376): 0: 598: 98.13