HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: TBB4B (P68371)
Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain)
Gene: TUBB4B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	19380743, 12577067
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 217 Hs			1 445
+	Hs
		924548 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		TBB3_HUMAN (1-443): 0: 714: 93.23
+	Hs
		428131 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		TBB5_HUMAN (1-429): 0: 711: 98.37
+	Hs
		924836 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		TBB6_HUMAN (1-432): 0: 706: 92.36
+	Hs
		411549 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		TBB5_HUMAN (1-429): 0: 711: 98.37
+	Hs
		411668 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		TBB4B_HUMAN (1-427): 0: 711: 100.00
+	Hs
		428198 PTK6_HUMAN (4-141): 7.14e-23: 97.1: 38.93		TBB5_HUMAN (1-429): 0: 711: 98.37
+	Hs
		933801 PTK6_HUMAN (4-141): 7.14e-23: 97.1: 38.93		TBB4B_HUMAN (1-427): 0: 711: 100.00
+	Hs
		548704 VAV_HUMAN (2-60): 8.95e-15: 74.6: 42.37		TBB3_HUMAN (1-443): 0: 714: 93.23
+	Hs
		428001 VAV_HUMAN (2-60): 8.95e-15: 74.6: 42.37		TBB5_HUMAN (1-429): 0: 711: 98.37
+	Hs
		548681 VAV_HUMAN (2-60): 8.95e-15: 74.6: 42.37		TBB4B_HUMAN (1-427): 0: 711: 100.00
+	Hs
		381112 VAV_HUMAN (2-60): 8.95e-15: 74.6: 42.37		TBB4A_HUMAN (1-427): 0: 706: 98.60
+	Hs
		427991 SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58		TBB5_HUMAN (1-429): 0: 711: 98.37
+	Hs
		381102 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		TBB4A_HUMAN (1-427): 0: 706: 98.60