HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: DLG4 (P78352)
Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)
Gene: DLG4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~SH3_1, Guanylate_kin~SH3_1, SH3_1~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0019903 - protein phosphatase binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 217 Hs			1 724
+	Mm
		1141133 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		DLG4_MOUSE (1-724): 0: 667: 99.59
+	Hs
		412128 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		DLG4_HUMAN (1-724): 0: 667: 100.00
+	Mm
		403445 SRC_MOUSE (161-215): 3.76e-11: 63.8: 31.58		DLG4_MOUSE (1-724): 0: 667: 99.59
+	Hs
		411718 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		SCRIB_HUMAN (58-243): 6.07e-25: 113: 40.72
+	Hs
		411698 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		DLG1_HUMAN (147-465): 1.89e-19: 95.5: 17.93
+	Hs
		411753 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		MPP7_HUMAN (8-289): 1.03e-19: 95.5: 12.50
+	Mm
		411930 LCK_MOUSE (3-202): 2.89e-37: 137: 28.44		DLG1_MOUSE (147-465): 2.02e-19: 95.5: 18.54
+	Hs
		411800 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		DLG5_HUMAN (40-245): 4.76e-17: 88.2: 32.54
+	Hs
		557746 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		DLG5_HUMAN (40-245): 4.76e-17: 88.2: 32.54
+	Hs
		433758 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		SCRIB_HUMAN (58-243): 6.07e-25: 113: 40.72
+	Hs
		433697 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		EM55_HUMAN (2-325): 2.03e-22: 103: 14.41
+	Hs
		522978 SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58		MPP2_HUMAN (2-383): 6.03e-22: 102: 14.54
+	Hs
		434043 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		PALS2_HUMAN (2-203): 5.54e-21: 99.4: 14.42
+	Hs
		159139 HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39		CSKP_HUMAN (6-200): 2.34e-19: 95.2: 14.29
+	Hs
		433731 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		DLG1_HUMAN (147-465): 1.89e-19: 95.5: 17.93
+	Hs
		433812 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		MPP7_HUMAN (8-289): 1.03e-19: 95.5: 12.50
+	Hs
		159138 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		CSKP_HUMAN (6-200): 2.34e-19: 95.2: 14.29
+	Rn
		73322 SRC_RAT (117-215): 2.55e-11: 64.2: 20.79		PALS1_RAT (3-238): 3.33e-18: 90.9: 12.30
+	Hs
		433909 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		DLG5_HUMAN (40-245): 4.76e-17: 88.2: 32.54