HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: KRT85 (P78386)
Keratin, type II cuticular Hb5 (Hair keratin K2.12) (Keratin-85) (K85) (Type II hair keratin Hb5) (Type-II keratin Kb25)
Gene: KRT85

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	19380743
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 217 Hs			1 507
+	Hs
		444533 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		K2C7_HUMAN (14-445): 2.34e-160: 465: 53.46
+	Hs
		380590 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		K2C1_HUMAN (92-448): 8.37e-123: 375: 54.44
+	Hs
		409046 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		K2C8_HUMAN (46-461): 7.91e-114: 346: 53.61
+	Hs
		924469 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		KRT83_HUMAN (1-505): 1.37e-105: 326: 79.84
+	Hs
		924576 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		KRT81_HUMAN (8-490): 1.97e-103: 320: 82.06
+	Hs
		213936 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		KRT86_HUMAN (7-501): 1.59e-101: 315: 81.65
+	Hs
		924679 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		K2C73_HUMAN (3-505): 1.24e-92: 294: 41.98
+	Hs
		924895 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		KRT82_HUMAN (1-506): 3.51e-90: 286: 59.45
+	Hs
		531551 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		K2C5_HUMAN (3-437): 1.8e-75: 250: 48.65
+	Hs
		359480 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		K2C6A_HUMAN (90-437): 5.41e-72: 240: 60.00
+	Hs
		280786 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		KRT36_HUMAN (28-434): 1.29e-68: 229: 26.47
+	Mm
		1060206 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		Q148Q7_MOUSE (4-437): 2.75e-66: 225: 51.21
+	Mm
		1141145 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		Q8BIS2_MOUSE (4-437): 3.88e-66: 224: 51.21
+	Hs
		924575 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		K1H2_HUMAN (8-434): 8.1e-67: 223: 24.07
+	Hs
		924741 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		KRT35_HUMAN (28-482): 1.18e-66: 223: 25.05
+	Mm
		403456 SRC_MOUSE (161-215): 3.76e-11: 63.8: 31.58		K2C5_MOUSE (3-437): 2.84e-73: 244: 48.85
+	Hs
		280771 HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39		KRT36_HUMAN (28-434): 1.29e-68: 229: 26.47
+	Hs
		442865 HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39		KRT35_HUMAN (28-482): 1.18e-66: 223: 25.05