HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: SHC2 (P98077)
SHC-transforming protein 2 (Protein Sck) (SHC-transforming protein B) (Src homology 2 domain-containing-transforming protein C2) (SH2 domain protein C2)
Gene: SHC2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	24430869
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~SH2, SH2~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 582
+	Hs
		666057 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SHC1_HUMAN (1-581): 2.34e-124: 379: 45.41
+	Mm
		957235 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		SHC1_MOUSE (1-581): 6.16e-124: 378: 44.89
+	Hs
		924646 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SHC4_HUMAN (6-580): 3.71e-121: 373: 39.16
+	Rn
		924995 GRB2_RAT (1-217): 6.71e-76: 229: 100.00		SHC1_RAT (96-581): 1.58e-119: 363: 50.30
+	Hs
		666104 GRAP_HUMAN (1-213): 2.32e-66: 205: 56.74		SHC1_HUMAN (1-581): 2.34e-124: 379: 45.41
+	Dm
		993194 GRAP_DROME (1-215): 5.1e-62: 194: 62.79		Q9V3C8_DROME (119-580): 3.81e-82: 265: 35.05
+	Hs
		924670 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		CLNK_HUMAN (201-579): 1.42e-40: 154: 13.33
+	Hs
		924543 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		GRB10_HUMAN (8-575): 3.58e-39: 153: 11.61
+	Hs
		522887 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SRC_HUMAN (326-573): 4.48e-39: 152: 15.06
+	Mm
		729751 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		BTK_MOUSE (281-581): 1.14e-37: 149: 13.29
+	Mm
		1141129 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		VAV2_MOUSE (380-581): 2.32e-36: 147: 14.49
+	Hs
		145977 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SH2B2_HUMAN (299-581): 3.55e-37: 148: 18.62
+	Hs
		855781 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		VAV2_HUMAN (380-578): 2.05e-36: 147: 13.74
+	Mm
		1141166 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		SH2B2_MOUSE (366-579): 1.6e-34: 140: 21.72
+	Hs
		557655 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		NCK1_HUMAN (456-574): 4.57e-35: 137: 24.59
+	Mm
		643091 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		P85A_MOUSE (427-578): 3.1e-23: 106: 19.23
+	Hs
		655306 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		P85A_HUMAN (427-578): 3.1e-23: 106: 19.23
+	Hs
		924735 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		P55G_HUMAN (482-580): 2.6e-16: 83.8: 33.01
+	Hs
		924447 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		GRB2_HUMAN (475-582): 5.69e-16: 79.1: 28.07
+	Dm
		665777 GRAP_DROME (1-215): 5.1e-62: 194: 62.79		CSW_DROME (482-578): 4.65e-14: 77.6: 21.78