HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: DAB2 (P98082)
Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Differentially-expressed protein 2)
Gene: DAB2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.688

Property	Details
Experiments	20936779, 10542228, 22323290, 17474147
Identification Methods	two hybrid, affinity chromatography technology, peptide array, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 770
+	Mm
		957139 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		DAB2_MOUSE (1-770): 1.47e-81: 278: 82.15
+	Hs
		782772 CSK_HUMAN (2-139): 3.92e-24: 100: 36.24		DAB2_HUMAN (1-770): 3.91e-90: 301: 100.00
+	Hs
		557659 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		DAB2_HUMAN (1-770): 3.91e-90: 301: 100.00
+	Rn
		924995 GRB2_RAT (1-217): 6.71e-76: 229: 100.00		SHC1_RAT (6-323): 7.39e-40: 155: 10.62
+	Hs
		412132 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		DAB2_HUMAN (1-770): 3.91e-90: 301: 100.00
+	Dm
		957161 GRAP_DROME (1-215): 5.1e-62: 194: 62.79		DAB_DROME (42-732): 1.16e-36: 151: 22.46
+	Hs
		554292 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MUC1_HUMAN (320-766): 7.89e-22: 103: 14.16
+	Hs
		203218 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SYNJ1_HUMAN (196-735): 1.47e-19: 96.5: 13.64
+	Hs
		411643 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		NUMB_HUMAN (22-635): 7.43e-47: 179: 14.20
+	Hs
		411911 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		NUMBL_HUMAN (18-585): 6.55e-41: 161: 13.54
+	Hs
		253523 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		CAPON_HUMAN (19-299): 8.52e-35: 141: 13.91
+	Mm
		956235 NCK1_MOUSE (5-145): 8.99e-23: 96.3: 33.14		DAB1_MOUSE (16-597): 6.31e-41: 160: 24.27
+	Hs
		269120 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		DAB1_HUMAN (16-597): 1.41e-40: 159: 24.62
+	Dm
		337651 ABL_DROME (4-135): 1e-22: 97.4: 37.68		DAB_DROME (42-732): 1.16e-36: 151: 22.46
+	Hs
		411582 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		MUC1_HUMAN (320-766): 7.89e-22: 103: 14.16
+	Hs
		203198 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		SYNJ1_HUMAN (196-735): 1.47e-19: 96.5: 13.64
+	Mm
		763385 FYN_MOUSE (161-215): 4.44e-14: 72.3: 31.58		DAB1_MOUSE (16-597): 6.31e-41: 160: 24.27
+	Hs
		253524 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		CAPON_HUMAN (19-299): 8.52e-35: 141: 13.91
+	Hs
		337335 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		MUC1_HUMAN (320-766): 7.89e-22: 103: 14.16
+	Hs
		203208 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		SYNJ1_HUMAN (196-735): 1.47e-19: 96.5: 13.64