HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: IL5RA (Q01344)
Interleukin-5 receptor subunit alpha (IL-5 receptor subunit alpha) (IL-5R subunit alpha) (IL-5R-alpha) (IL-5RA) (CDw125) (CD antigen CD125)
Gene: IL5RA

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 420
+	Hs
		645898 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		IL3RA_HUMAN (26-409): 1.5e-61: 205: 24.06
+	Hs
		682260 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		IL2RG_HUMAN (80-400): 8.91e-48: 168: 17.26
+	Hs
		500956 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		GHR_HUMAN (106-398): 9.47e-43: 160: 17.54
+	Mm
		540268 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		EPOR_MOUSE (97-392): 7.47e-41: 153: 17.26
+	Hs
		581157 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		EPOR_HUMAN (113-391): 7.72e-35: 136: 18.54
+	Hs
		581163 GRAP_HUMAN (1-213): 2.32e-66: 205: 56.74		EPOR_HUMAN (113-391): 7.72e-35: 136: 18.54
+	Hs
		924809 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		CSF3R_HUMAN (123-339): 1.07e-18: 90.7: 15.58
+	Mm
		770716 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		CSF3R_MOUSE (121-339): 2.03e-16: 83.7: 16.17
+	Hs
		872630 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		EPHA4_HUMAN (29-239): 3.11e-16: 83: 10.39
+	Hs
		562545 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		IL7RA_HUMAN (211-385): 2.36e-15: 79.5: 13.54
+	Mm
		872621 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		EPHB2_MOUSE (25-238): 4.47e-14: 76.4: 11.92
+	Hs
		665467 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		EPHA8_HUMAN (29-239): 3.18e-14: 76.8: 11.40
+	Hs
		665574 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		EPHB2_HUMAN (25-238): 4.58e-14: 76.4: 11.92
+	Hs
		665389 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		EPHA3_HUMAN (29-256): 1.36e-12: 71.8: 13.25
+	Hs
		817315 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		LEPR_HUMAN (38-387): 4.8e-12: 70.2: 15.12
+	Hs
		872610 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		EPHB1_HUMAN (23-237): 2.97e-11: 67.6: 9.79
+	Hs
		770194 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		IL6RB_HUMAN (12-340): 1.37e-10: 65.3: 9.86
+	Hs
		500941 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		GHR_HUMAN (106-398): 9.47e-43: 160: 17.54
+	Hs
		411565 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		PTPRF_HUMAN (13-274): 3.43e-18: 89.5: 12.03
+	Mm
		411919 LCK_MOUSE (3-202): 2.89e-37: 137: 28.44		CSF3R_MOUSE (121-339): 2.03e-16: 83.7: 16.17