HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: OCRL (Q01968)
Inositol polyphosphate 5-phosphatase OCRL (EC 3.1.3.36) (EC 3.1.3.56) (Inositol polyphosphate 5-phosphatase OCRL-1) (OCRL-1) (Lowe oculocerebrorenal syndrome protein) (Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase) (EC 3.1.3.86)
Gene: OCRL

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	9038219
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 901
+	Hs
		411678 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		OCRL_HUMAN (1-901): 0: 1075: 100.00
+	Hs
		412137 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		OCRL_HUMAN (1-901): 0: 1075: 100.00
+	Hs
		433324 YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91		OCRL_HUMAN (1-901): 0: 1075: 100.00
+	Hs
		203218 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SYNJ1_HUMAN (218-733): 8.18e-121: 403: 24.37
+	Hs
		166042 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SYNJ2_HUMAN (223-584): 5.73e-119: 397: 31.24
+	Dm
		993185 GRAP_DROME (1-215): 5.1e-62: 194: 62.79		Q5U0V7_DROME (223-569): 3.8e-118: 390: 32.90
+	Mm
		1141165 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		SHIP1_MOUSE (204-631): 6.78e-103: 348: 25.33
+	Hs
		924742 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SHIP1_HUMAN (204-743): 3.04e-103: 349: 21.23
+	Hs
		176424 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SHIP2_HUMAN (184-644): 2.78e-101: 344: 24.95
+	Hs
		203198 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		SYNJ1_HUMAN (218-733): 8.18e-121: 403: 24.37
+	Hs
		203208 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		SYNJ1_HUMAN (218-733): 8.18e-121: 403: 24.37
+	Hs
		166030 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		SYNJ2_HUMAN (223-584): 5.73e-119: 397: 31.24
+	Hs
		166023 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		SYNJ2_HUMAN (223-584): 5.73e-119: 397: 31.24
+	Hs
		166056 ITSN2_HUMAN (2-61): 5.91e-15: 75: 36.67		SYNJ2_HUMAN (223-584): 5.73e-119: 397: 31.24
+	Hs
		166024 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		SYNJ2_HUMAN (223-584): 5.73e-119: 397: 31.24
+	Hs
		557759 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		SHIP1_HUMAN (204-743): 3.04e-103: 349: 21.23
+	Mm
		337638 ABL1_MOUSE (4-139): 4.07e-22: 95.9: 35.46		SHIP1_MOUSE (204-631): 6.78e-103: 348: 25.33
+	Hs
		176332 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		SHIP2_HUMAN (184-644): 2.78e-101: 344: 24.95
+	Hs
		69199 A9UF07_HUMAN (4-139): 1.63e-21: 94: 35.46		SHIP2_HUMAN (184-644): 2.78e-101: 344: 24.95
+	Hs
		433436 YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91		SHIP1_HUMAN (204-743): 3.04e-103: 349: 21.23