HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: AKA12 (Q02952)
A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen)
Gene: AKAP12

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	31980649, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005938 - cell cortex GO:0007165 - signal transduction
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 217 Hs			1 1782
+	Hs
		442810 HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39		AKA12_HUMAN (1-1782): 0: 676: 100.00
+	Hs
		433709 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		AKA12_HUMAN (1-1782): 0: 676: 100.00
+	Hs
		522923 SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58		AKA12_HUMAN (1-1782): 0: 676: 100.00
+	Hs
		807680 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MAP1B_HUMAN (3-1107): 1.08e-90: 331: 8.57
+	Hs
		924808 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MINT_HUMAN (7-1665): 1.47e-54: 213: 10.50
+	Hs
		557777 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		MINT_HUMAN (7-1665): 1.47e-54: 213: 10.50
+	Hs
		517796 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		NFH_HUMAN (612-1138): 3.15e-12: 73.9: 14.91
+	Hs
		924760 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PRG4_HUMAN (3-808): 1.87e-09: 65: 10.60
+	Hs
		924473 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MAP1A_HUMAN (8-653): 8.53e-09: 63: 8.76
+	Hs
		152571 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		KMT2D_HUMAN (47-764): 3.85e-43: 176: 11.48
+	Hs
		337387 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		KI67_HUMAN (1-1782): 2.94e-11: 71.2: 11.31
+	Hs
		412078 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		KI67_HUMAN (1-1782): 2.94e-11: 71.2: 11.31
+	Hs
		855816 VAV2_HUMAN (3-56): 4.83e-11: 63.5: 38.18		TITIN_HUMAN (21-962): 3.34e-13: 77.6: 11.72
+	Hs
		434084 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		SRRM2_HUMAN (4-1096): 6.49e-11: 70: 7.25
+	Hs
		522847 SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58		KI67_HUMAN (1-1782): 2.94e-11: 71.2: 11.31
+	Hs
		789101 FRK_HUMAN (150-212): 6.98e-11: 62.7: 27.78		KI67_HUMAN (1-1782): 2.94e-11: 71.2: 11.31