HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: DYST (Q03001)
Dystonin (230 kDa bullous pemphigoid antigen) (230/240 kDa bullous pemphigoid antigen) (Bullous pemphigoid antigen 1) (BPA) (Bullous pemphigoid antigen) (Dystonia musculorum protein) (Hemidesmosomal plaque protein)
Gene: DST

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	12577067
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005938 - cell cortex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 7570
+	Hs
		411682 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		DYST_HUMAN (1-7570): 0: 2600: 100.00
+	Hs
		974160 ITSN2_HUMAN (2-61): 5.91e-15: 75: 36.67		DYST_HUMAN (1-7570): 0: 2600: 100.00
+	Hs
		521521 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		ACTN1_HUMAN (3770-4283): 1.06e-26: 123: 10.00
+	Hs
		924482 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SPTB2_HUMAN (5709-7570): 7.99e-22: 108: 12.95
+	Hs
		924555 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SPTN1_HUMAN (269-874): 2.44e-13: 80.3: 13.42
+	Hs
		924586 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PLEC_HUMAN (1777-1974): 1.7e-12: 77.5: 19.19
+	Hs
		885226 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		EPIPL_HUMAN (1651-1891): 1.02e-10: 71.7: 20.73
+	Hs
		411676 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		SPTB2_HUMAN (5709-7570): 7.99e-22: 108: 12.95
+	Hs
		411889 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		MACF1_HUMAN (351-1936): 4.95e-21: 105: 11.05
+	Hs
		164551 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		SPTN2_HUMAN (5708-7163): 4.91e-17: 92.5: 14.91
+	Hs
		411637 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		UTRN_HUMAN (264-1530): 1.26e-14: 84.8: 9.65
+	Hs
		411715 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		SPTN1_HUMAN (269-874): 2.44e-13: 80.3: 13.42
+	Hs
		411724 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		GOGB1_HUMAN (1119-1866): 1.3e-10: 71.3: 6.59
+	Hs
		411581 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		DESP_HUMAN (1555-1738): 2.9e-09: 67: 28.50
+	Hs
		337470 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		SPTN1_HUMAN (269-874): 2.44e-13: 80.3: 13.42
+	Hs
		993249 PTK6_HUMAN (4-141): 7.14e-23: 97.1: 38.93		ACTN3_HUMAN (453-929): 1.33e-11: 74.3: 10.26
+	Hs
		551599 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		DESP_HUMAN (1555-1738): 2.9e-09: 67: 28.50
+	Hs
		1068630 Q96D37_HUMAN (2-60): 8.82e-15: 74.6: 42.37		PLEC_HUMAN (1777-1974): 1.7e-12: 77.5: 19.19
+	Hs
		548710 VAV_HUMAN (2-60): 8.95e-15: 74.6: 42.37		PLEC_HUMAN (1777-1974): 1.7e-12: 77.5: 19.19
+	Hs
		1059285 ITSN2_HUMAN (2-61): 5.91e-15: 75: 36.67		GOGB1_HUMAN (1119-1866): 1.3e-10: 71.3: 6.59