HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: K1C17 (Q04695)
Keratin, type I cytoskeletal 17 (39.1) (Cytokeratin-17) (CK-17) (Keratin-17) (K17)
Gene: KRT17

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	12577067, 19380743
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 432
+	Hs
		445027 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		K1C16_HUMAN (80-410): 1.7e-159: 460: 79.28
+	Hs
		359329 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		K1C14_HUMAN (82-430): 1.15e-151: 440: 82.40
+	Hs
		444346 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		K1C19_HUMAN (77-394): 1.39e-146: 424: 73.59
+	Hs
		580010 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		K1C15_HUMAN (83-426): 2.02e-141: 413: 68.66
+	Hs
		280492 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		KT33A_HUMAN (30-405): 1.98e-141: 411: 52.39
+	Hs
		531343 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		K1C10_HUMAN (79-389): 1.15e-123: 372: 69.75
+	Hs
		924574 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		KT33B_HUMAN (77-395): 1.68e-118: 353: 59.88
+	Hs
		280559 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		KRT34_HUMAN (77-395): 9.16e-117: 348: 58.62
+	Hs
		924576 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		KRT81_HUMAN (21-397): 2.65e-91: 287: 26.46
+	Hs
		924469 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		KRT83_HUMAN (21-402): 2.82e-91: 286: 26.63
+	Hs
		924470 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		KRT85_HUMAN (3-397): 7.18e-91: 285: 27.27
+	Hs
		213936 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		KRT86_HUMAN (21-397): 6.62e-90: 282: 26.46
+	Hs
		924679 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		K2C73_HUMAN (4-398): 3.6e-88: 279: 25.68
+	Hs
		924741 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		KRT35_HUMAN (2-395): 1.01e-82: 263: 52.22
+	Hs
		280786 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		KRT36_HUMAN (2-395): 8.29e-81: 258: 55.72
+	Hs
		924575 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		K1H2_HUMAN (1-395): 5.85e-80: 255: 50.13
+	Hs
		531551 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		K2C5_HUMAN (50-398): 1.34e-72: 240: 25.07
+	Hs
		359480 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		K2C6A_HUMAN (50-414): 3.75e-72: 238: 23.71
+	Hs
		337481 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		K1H1_HUMAN (39-405): 3.5e-84: 265: 53.13
+	Hs
		924895 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		KRT82_HUMAN (135-429): 3.24e-10: 64: 14.87