HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: RON (Q04912)
Macrophage-stimulating protein receptor (MSP receptor) (EC 2.7.10.1) (CDw136) (Protein-tyrosine kinase 8) (p185-Ron) (CD antigen CD136) [Cleaved into: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain]
Gene: MST1R

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	7488076, 8918464
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 1400
+	Mm
		101586 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		F8VQL0_MOUSE (1-1362): 0: 1072: 33.64
+	Hs
		441477 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MET_HUMAN (1-1391): 0: 1065: 32.44
+	Hs
		665389 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		EPHA3_HUMAN (568-1377): 1.49e-169: 535: 16.39
+	Hs
		665574 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		EPHB2_HUMAN (557-1369): 6.07e-165: 525: 17.12
+	Hs
		872422 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		EPHA5_HUMAN (557-1362): 5.19e-165: 524: 16.53
+	Mm
		872621 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		EPHB2_MOUSE (557-1369): 9.59e-165: 522: 17.00
+	Hs
		665200 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		EPHA2_HUMAN (557-1377): 5.9e-160: 509: 16.75
+	Hs
		665467 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		EPHA8_HUMAN (568-1368): 1.37e-159: 509: 17.12
+	Hs
		600548 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		EPHA1_HUMAN (727-1375): 8.38e-134: 438: 23.79
+	Hs
		507939 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		FGFR1_HUMAN (767-1397): 8.56e-114: 379: 22.74
+	Hs
		609244 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		FGFR3_HUMAN (1015-1400): 5.83e-114: 379: 32.20
+	Hs
		601492 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		FGFR2_HUMAN (784-1397): 2.76e-113: 378: 23.33
+	Mm
		710138 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		FAK1_MOUSE (1022-1395): 1.71e-104: 359: 30.73
+	Mm
		963044 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		UFO_MOUSE (1062-1348): 4.1e-57: 216: 41.14
+	Hs
		674385 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		UFO_HUMAN (1062-1348): 3.97e-56: 213: 40.47
+	Hs
		435602 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		IGF1R_HUMAN (1072-1343): 3.56e-52: 204: 37.93
+	Hs
		411352 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		INSR_HUMAN (1073-1338): 8.47e-51: 199: 38.73
+	Hs
		782767 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		CSK_HUMAN (1086-1344): 9.72e-51: 188: 40.00
+	Hs
		195974 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PLXB1_HUMAN (522-1068): 1.81e-42: 173: 17.96
+	Hs
		165186 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PLXB2_HUMAN (508-1070): 7.22e-25: 115: 19.34