HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: DYN1 (Q05193)
Dynamin-1 (EC 3.6.5.5) (Dynamin) (Dynamin I)
Gene: DNM1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	1.00	0.985

Property	Details
Experiments	28514442, 7597091, 9478994, 31980649, 8119878, 9009162, 33961781, 19380743, 21706016, 15834155, 17244534, 17474147, unassigned2173, 10206341
Identification Methods	affinity chromatography technology, pull down, far western blotting, peptide array, surface plasmon resonance, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0003723 - RNA binding GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0019901 - protein kinase binding GO:0031623 - receptor internalization and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 864
+	Mm
		760450 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		DYN1_MOUSE (1-845): 0: 1081: 99.65
+	Rn
		599402 GRB2_RAT (1-217): 6.71e-76: 229: 100.00		DYN1_RAT (1-864): 0: 1081: 98.03
+	Mm
		760474 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		DYN2_MOUSE (1-860): 0: 1022: 79.13
+	Hs
		840663 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		DYN2_HUMAN (1-860): 0: 1021: 78.91
+	Mm
		1141147 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		DYN3_MOUSE (1-860): 0: 1012: 78.55
+	Hs
		924956 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		DYN3_HUMAN (1-860): 0: 998: 78.12
+	Hs
		840686 GRAP_HUMAN (1-213): 2.32e-66: 205: 56.74		DYN2_HUMAN (1-860): 0: 1021: 78.91
+	Hs
		557664 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		DYN1_HUMAN (1-864): 0: 1087: 100.00
+	Hs
		337437 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		DYN1_HUMAN (1-864): 0: 1087: 100.00
+	Hs
		411645 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		DYN2_HUMAN (1-860): 0: 1021: 78.91
+	Dm
		649302 GRAP_DROME (1-215): 5.1e-62: 194: 62.79		DYN_DROME (6-859): 0: 963: 65.41
+	Hs
		337399 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		DYN2_HUMAN (1-860): 0: 1021: 78.91
+	Hs
		840840 ITSN2_HUMAN (2-61): 5.91e-15: 75: 36.67		DYN2_HUMAN (1-860): 0: 1021: 78.91
+	Hs
		337597 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		DYN3_HUMAN (1-860): 0: 998: 78.12
+	Hs
		412090 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		DYN2_HUMAN (1-860): 0: 1021: 78.91
+	Hs
		442794 HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39		DYN2_HUMAN (1-860): 0: 1021: 78.91
+	Hs
		840702 ITSN1_HUMAN (137-216): 1.36e-12: 68.1: 25.00		DYN2_HUMAN (1-860): 0: 1021: 78.91
+	Hs
		412411 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		DYN3_HUMAN (1-860): 0: 998: 78.12
+	Ce
		220206 SRC2_CAEEL (118-215): 1.65e-14: 73.4: 22.00		DYN1_CAEEL (3-805): 0: 916: 64.18
+	Ce
		666206 SEM5_CAEEL (3-69): 6.24e-14: 70: 28.36		DYN1_CAEEL (3-805): 0: 916: 64.18