HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: PTN12 (Q05209)
Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1)
Gene: PTPN12

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.870

Property	Details
Experiments	28675297, 9135065, 21706016
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	SH2~Y_phosphatase
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0017124 - SH3 domain binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 780
+	Mm
		420374 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		PTPRC_MOUSE (13-686): 9.35e-150: 472: 18.93
+	Hs
		924971 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PTN22_HUMAN (1-779): 6.27e-132: 413: 32.01
+	Hs
		665853 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PTN6_HUMAN (7-361): 1.95e-132: 407: 31.25
+	Hs
		573654 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PTN1_HUMAN (27-409): 1.5e-127: 389: 24.46
+	Mm
		719305 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		PTN11_MOUSE (7-351): 2.04e-124: 387: 31.48
+	Hs
		924502 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PTN11_HUMAN (7-351): 1.65e-124: 387: 31.48
+	Rn
		783504 GRB2_RAT (1-217): 6.71e-76: 229: 100.00		PTN11_RAT (7-351): 1.11e-123: 385: 31.48
+	Mm
		411913 LCK_MOUSE (3-202): 2.89e-37: 137: 28.44		PTPRC_MOUSE (13-686): 9.35e-150: 472: 18.93
+	Hs
		924822 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PTN18_HUMAN (14-446): 4.35e-123: 378: 32.66
+	Hs
		411557 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		PTPRC_HUMAN (13-678): 1.57e-143: 456: 19.30
+	Mm
		574006 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		PTPRA_MOUSE (7-295): 2.45e-106: 346: 32.08
+	Hs
		577009 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PTPRA_HUMAN (7-295): 5.6e-105: 342: 32.08
+	Hs
		617047 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PTPRE_HUMAN (7-295): 3.58e-101: 329: 31.54
+	Hs
		411596 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		PTPRB_HUMAN (7-314): 1.22e-123: 410: 29.62
+	Hs
		411612 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		PTN6_HUMAN (7-361): 1.95e-132: 407: 31.25
+	Hs
		146925 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PTPRT_HUMAN (8-296): 7.41e-63: 231: 25.93
+	Hs
		411565 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		PTPRF_HUMAN (8-299): 2.83e-90: 313: 31.99
+	Hs
		924529 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PTPRJ_HUMAN (49-297): 6.23e-46: 179: 39.13
+	Hs
		411609 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		PTPRM_HUMAN (7-296): 8.79e-62: 228: 24.50
+	Hs
		411597 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		PTPRG_HUMAN (8-299): 1.84e-52: 200: 24.50