HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: PTN11 (Q06124)
Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)
Gene: PTPN11

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.992

The method score is based on:

Property Details
Experiments 7534299, 20473329, 8959326, 16371368, 9254654, 8647120, 9660791, 10212213, 8702859, 28514442, 10747947, 8041791, 31980649, 9824671, 8995399, 9362449, 9632781, 10080542, 33961781, 34407391 and 9 others

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Identification Methods affinity chromatography technology, pull down, far western blotting, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, tandem affinity purification
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains SH2~SH2, SH2~Y_phosphatase, SH2~SH3_1
Common GO terms GO:0001784 - phosphotyrosine residue binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
and 3 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 217
Hs

1 593
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Last updated: 15 Jul 2024