HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: SOS1 (Q07889)
Son of sevenless homolog 1 (SOS-1)
Gene: SOS1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 1.00 0.997

The method score is based on:

Property Details
Experiments 28166272, 7559490, 9797459, 7516467, 11726515, 8816480, 11997436, 8188688, 32203420, 7510700, 10716926, 8810325, 10207103, 10570290, 10025673, 9716598, 28514442, 20473329, 15192046, 9478994 and 43 others

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Identification Methods affinity chromatography technology, pull down, unspecified method, two hybrid, far western blotting, anti tag coimmunoprecipitation, isothermal titration calorimetry, peptide array, coimmunoprecipitation, surface plasmon resonance and 2 others

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Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains PH~SH3_1, RhoGEF~SH3_1
Common GO terms GO:0005154 - epidermal growth factor receptor binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0007165 - signal transduction
and 9 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 217
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024