HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: FLII (Q13045)
Protein flightless-1 homolog
Gene: FLII

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	12577067
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	LRR_8~SH2, LRR_4~SH3_1
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 217 Hs			1 1269
+	Hs
		411699 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		FLII_HUMAN (1-1269): 0: 1206: 100.00
+	Hs
		413883 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		GELS_HUMAN (481-1269): 0: 798: 24.85
+	Hs
		413803 YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91		GELS_HUMAN (481-1269): 0: 798: 24.85
+	Hs
		413814 SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58		GELS_HUMAN (481-1269): 0: 798: 24.85
+	Hs
		924994 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SCIN_HUMAN (906-1269): 3.84e-72: 258: 18.04
+	Hs
		313798 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SVIL_HUMAN (1056-1267): 1.52e-21: 104: 17.69
+	Hs
		448963 SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58		VILI_HUMAN (892-1269): 3.51e-57: 215: 15.42
+	Hs
		411826 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		ERBIN_HUMAN (10-376): 1.85e-23: 110: 28.27
+	Hs
		433956 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		ERBIN_HUMAN (10-376): 1.85e-23: 110: 28.27
+	Hs
		313728 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		SVIL_HUMAN (1056-1267): 1.52e-21: 104: 17.69
+	Hs
		433978 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		LRRC1_HUMAN (116-379): 5.94e-20: 97.1: 29.76