HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: LCP2 (Q13094)
Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76)
Gene: LCP2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.97	1.00	0.985

Property	Details
Experiments	32296183, 10204582, 10224278, 9716598, 12176364, 25416956, 7706237, 9565634, 11314042, 8695800, 8995445, 20936779, 19380743, unassigned1304, 17235283, 15929943
Identification Methods	two hybrid, affinity chromatography technology, unspecified method, pull down, two hybrid array, two hybrid prey pooling approach, validated two hybrid, tandem affinity purification, two hybrid pooling approach, peptide array and 1 others more... anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	SH2~SH2, SH2~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0005911 - cell-cell junction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 533
+	Mm
		1141127 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		LCP2_MOUSE (1-531): 8.21e-72: 240: 80.98
+	Mm
		1141385 GRAP_MOUSE (1-213): 7.52e-66: 204: 57.67		LCP2_MOUSE (1-531): 8.21e-72: 240: 80.98
+	Hs
		411700 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00
+	Hs
		924670 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		CLNK_HUMAN (182-528): 1.05e-42: 159: 25.00
+	Hs
		924727 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		BLNK_HUMAN (75-520): 4.29e-35: 139: 24.28
+	Mm
		222321 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		O54737_MOUSE (52-523): 4.71e-33: 134: 19.88
+	Hs
		924632 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		TENS2_HUMAN (79-512): 3.43e-30: 127: 17.32
+	Hs
		557674 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00
+	Mm
		1141384 NCK1_MOUSE (5-145): 8.99e-23: 96.3: 33.14		LCP2_MOUSE (1-531): 8.21e-72: 240: 80.98
+	Hs
		203218 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SYNJ1_HUMAN (10-466): 1.18e-22: 104: 11.71
+	Hs
		554292 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MUC1_HUMAN (87-469): 7.93e-15: 79.7: 9.92
+	Hs
		1261030 VAV3_HUMAN (1-212): 1.16e-43: 157: 22.00		BLNK_HUMAN (75-520): 4.29e-35: 139: 24.28
+	Hs
		924760 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PRG4_HUMAN (53-459): 6.87e-09: 60.8: 10.39
+	Hs
		203198 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		SYNJ1_HUMAN (10-466): 1.18e-22: 104: 11.71
+	Hs
		557750 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		BLNK_HUMAN (75-520): 4.29e-35: 139: 24.28
+	Hs
		782795 CSK_HUMAN (2-139): 3.92e-24: 100: 36.24		TENS2_HUMAN (79-512): 3.43e-30: 127: 17.32
+	Hs
		782797 CSK_HUMAN (2-139): 3.92e-24: 100: 36.24		TENS3_HUMAN (83-512): 1.87e-28: 122: 12.50
+	Hs
		411582 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		MUC1_HUMAN (87-469): 7.93e-15: 79.7: 9.92
+	Hs
		782828 CSK_HUMAN (2-139): 3.92e-24: 100: 36.24		TENS1_HUMAN (85-512): 1.44e-22: 104: 14.61
+	Hs
		203208 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		SYNJ1_HUMAN (10-466): 1.18e-22: 104: 11.71