HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: MP2K5 (Q13163)
Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (EC 2.7.12.2) (MAPK/ERK kinase 5) (MEK 5)
Gene: MAP2K5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PB1~SH3_1
Common GO terms	GO:0007165 - signal transduction GO:0048009 - insulin-like growth factor receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 448
+	Hs
		924536 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		PAK1_HUMAN (94-420): 7.29e-104: 321: 28.11
+	Hs
		411606 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		MARK3_HUMAN (113-430): 1.45e-116: 359: 20.49
+	Hs
		411778 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		MARK2_HUMAN (113-445): 4.08e-116: 359: 20.59
+	Hs
		681710 CSK_HUMAN (2-139): 3.92e-24: 100: 36.24		AKT1_HUMAN (59-444): 3.89e-123: 368: 17.82
+	Hs
		681838 PTK6_HUMAN (4-141): 7.14e-23: 97.1: 38.93		AKT1_HUMAN (59-444): 3.89e-123: 368: 17.82
+	Hs
		805381 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MP2K3_HUMAN (158-418): 1.56e-66: 218: 45.09
+	Hs
		412046 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		AKT1_HUMAN (59-444): 3.89e-123: 368: 17.82
+	Hs
		433609 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		AKT2_HUMAN (111-442): 5.15e-125: 373: 20.86
+	Mm
		403418 SRC_MOUSE (161-215): 3.76e-11: 63.8: 31.58		AKT1_MOUSE (59-444): 7.18e-124: 370: 17.57
+	Hs
		522810 SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58		AKT1_HUMAN (59-444): 3.89e-123: 368: 17.82
+	Hs
		337455 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		STK4_HUMAN (146-445): 8.05e-108: 329: 31.09
+	Hs
		433589 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		MARK3_HUMAN (113-430): 1.45e-116: 359: 20.49
+	Hs
		433850 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		MARK2_HUMAN (113-445): 4.08e-116: 359: 20.59
+	Hs
		557676 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		PAK1_HUMAN (94-420): 7.29e-104: 321: 28.11
+	Mm
		292046 NCK1_MOUSE (5-145): 8.99e-23: 96.3: 33.14		PAK1_MOUSE (94-420): 7.68e-103: 318: 27.81
+	Mm
		1144396 NCK1_MOUSE (5-145): 8.99e-23: 96.3: 33.14		MP2K2_MOUSE (139-448): 6.76e-103: 313: 40.00
+	Hs
		412163 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		STK4_HUMAN (146-445): 8.05e-108: 329: 31.09
+	Hs
		548687 VAV_HUMAN (2-60): 8.95e-15: 74.6: 42.37		MP2K1_HUMAN (139-448): 1.69e-102: 312: 40.57
+	Hs
		433739 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		PAK1_HUMAN (94-420): 7.29e-104: 321: 28.11
+	Hs
		522922 SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58		MP2K1_HUMAN (139-448): 1.69e-102: 312: 40.57