HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: CBLB (Q13191)
E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B)
Gene: CBLB

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 0.60 0.766

The method score is based on:

Property Details
Experiments 25416956, 29997244, 26264872, 10086340, 9614102, 10022120, 28514442, 27107012, 31980649, 33961781, 20936779, 21900206, 21706016, 12577067, unassigned1913, 32814053, unassigned2173
Identification Methods two hybrid, fluorescent resonance energy transfer, affinity chromatography technology, pull down, split luciferase complementation, mammalian protein protein interaction trap, two hybrid array, luminescence based mammalian interactome mapping, two hybrid prey pooling approach, validated two hybrid and 3 others

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Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0001784 - phosphotyrosine residue binding
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0007165 - signal transduction
and 1 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 217
Hs

1 982
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+ Rn
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Last updated: 15 Jul 2024