HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: SNTA1 (Q13424)
Alpha-1-syntrophin (59 kDa dystrophin-associated protein A1 acidic component 1) (Pro-TGF-alpha cytoplasmic domain-interacting protein 1) (TACIP1) (Syntrophin-1)
Gene: SNTA1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	11278583
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 217 Hs			1 505
+	Oc
		101981 G1SR27_RABIT (1-217): 6.71e-76: 229: 100.00		SNTA1_RABIT (1-505): 1.2e-175: 505: 93.47
+	Mm
		1141130 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		SNTA1_MOUSE (1-505): 3.16e-173: 499: 91.55
+	Hs
		411705 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		SNTB2_HUMAN (3-504): 3.86e-150: 441: 45.28
+	Hs
		789112 FRK_HUMAN (150-212): 6.98e-11: 62.7: 27.78		SNTB2_HUMAN (3-504): 3.86e-150: 441: 45.28
+	Mm
		1141133 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		DLG4_MOUSE (44-364): 9.35e-24: 107: 16.91
+	Hs
		924466 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		DLG4_HUMAN (44-364): 8.62e-24: 107: 16.91
+	Hs
		924701 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		LNX2_HUMAN (30-296): 7.59e-19: 91.9: 17.04
+	Hs
		924718 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		LNX1_HUMAN (38-318): 2.23e-18: 90.4: 15.49
+	Mm
		411930 LCK_MOUSE (3-202): 2.89e-37: 137: 28.44		DLG1_MOUSE (15-364): 1.58e-25: 112: 17.49
+	Hs
		411698 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		DLG1_HUMAN (1-320): 1.18e-24: 110: 15.34
+	Hs
		548755 VAV_HUMAN (2-60): 8.95e-15: 74.6: 42.37		LIN7C_HUMAN (83-172): 1.22e-29: 116: 40.00
+	Hs
		442887 HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39		GOPC_HUMAN (55-169): 1.74e-29: 122: 41.38
+	Hs
		433490 YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91		LIN7C_HUMAN (83-172): 1.22e-29: 116: 40.00
+	Hs
		412128 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		DLG4_HUMAN (44-364): 8.62e-24: 107: 16.91
+	Hs
		433731 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		DLG1_HUMAN (1-320): 1.18e-24: 110: 15.34
+	Mm
		403445 SRC_MOUSE (161-215): 3.76e-11: 63.8: 31.58		DLG4_MOUSE (44-364): 9.35e-24: 107: 16.91
+	Hs
		523076 SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58		LNX1_HUMAN (38-318): 2.23e-18: 90.4: 15.49
+	Hs
		275210 GRAP2_HUMAN (3-55): 1.58e-10: 61.3: 39.62		LNX2_HUMAN (30-296): 7.59e-19: 91.9: 17.04
+	Hs
		275214 GRAP2_HUMAN (3-55): 1.58e-10: 61.3: 39.62		LNX1_HUMAN (38-318): 2.23e-18: 90.4: 15.49