HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: RAGE (Q15109)
Advanced glycosylation end product-specific receptor (Receptor for advanced glycosylation end products)
Gene: AGER

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	21706016, 17474147
Identification Methods	affinity chromatography technology, peptide array, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 217 Hs			1 404
+	Hs
		557699 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		RAGE_HUMAN (1-404): 8.32e-69: 224: 100.00
+	Hs
		924597 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MYLK_HUMAN (17-117): 2.21e-12: 71.2: 14.85
+	Hs
		412074 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		MUC18_HUMAN (22-301): 1.39e-58: 203: 24.92
+	Hs
		433279 YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91		MUC18_HUMAN (22-301): 1.39e-58: 203: 24.92
+	Hs
		557632 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		DCC_HUMAN (5-362): 3.01e-46: 172: 14.02
+	Hs
		433634 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		MUC18_HUMAN (22-301): 1.39e-58: 203: 24.92
+	Hs
		522843 SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58		MUC18_HUMAN (22-301): 1.39e-58: 203: 24.92
+	Hs
		433742 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		PTK7_HUMAN (13-401): 8.43e-35: 138: 16.95
+	Dm
		219802 ABL_DROME (4-135): 1e-22: 97.4: 37.68		O44924_DROME (229-401): 2.92e-18: 89.3: 15.46
+	Hs
		557704 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		MYLK_HUMAN (17-117): 2.21e-12: 71.2: 14.85
+	Hs
		434019 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		ROBO2_HUMAN (232-401): 1.01e-18: 90.8: 17.55
+	Hs
		434111 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		ROBO1_HUMAN (232-401): 5.96e-17: 85.4: 15.96
+	Hs
		433507 YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91		TUTLB_HUMAN (243-403): 5.17e-11: 66.6: 16.16
+	Hs
		523003 SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58		MYLK_HUMAN (17-117): 2.21e-12: 71.2: 14.85
+	Hs
		434081 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		TUTLB_HUMAN (243-403): 5.17e-11: 66.6: 16.16
+	Hs
		523211 SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58		TUTLB_HUMAN (243-403): 5.17e-11: 66.6: 16.16
+	Hs
		855816 VAV2_HUMAN (3-56): 4.83e-11: 63.5: 38.18		TITIN_HUMAN (17-390): 4.1e-09: 60.8: 12.21