HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: RB11B (Q15907)
Ras-related protein Rab-11B (EC 3.6.5.2) (GTP-binding protein YPT3)
Gene: RAB11B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	32814053
Identification Methods	two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005794 - Golgi apparatus GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 217 Hs			1 218
+	Hs
		913994 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		RB11A_HUMAN (1-218): 1.25e-91: 269: 90.37
+	Hs
		557649 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		RB11A_HUMAN (1-218): 1.25e-91: 269: 90.37
+	Hs
		557646 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		RAB25_HUMAN (2-218): 1.3e-83: 249: 60.63
+	Hs
		523004 SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58		RB11B_HUMAN (1-218): 2.77e-95: 278: 100.00
+	Hs
		433312 YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91		RB11A_HUMAN (1-218): 1.25e-91: 269: 90.37
+	Hs
		914091 ITSN1_HUMAN (137-216): 1.36e-12: 68.1: 25.00		RB11A_HUMAN (1-218): 1.25e-91: 269: 90.37
+	Hs
		522882 SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58		RB11A_HUMAN (1-218): 1.25e-91: 269: 90.37
+	Hs
		433302 YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91		RAB25_HUMAN (2-218): 1.3e-83: 249: 60.63
+	Hs
		433306 YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91		RAB2A_HUMAN (8-178): 5.89e-61: 191: 55.56
+	Hs
		433674 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		RAB2A_HUMAN (8-178): 5.89e-61: 191: 55.56
+	Hs
		522878 SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58		RAB2A_HUMAN (8-178): 5.89e-61: 191: 55.56