HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: NTRK3 (Q16288)
NT-3 growth factor receptor (EC 2.7.10.1) (GP145-TrkC) (Trk-C) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase)
Gene: NTRK3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	LRR_8~SH2, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 839
+	Hs
		924603 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		NTRK2_HUMAN (6-839): 0: 557: 52.87
+	Hs
		384619 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Rn
		728442 GRB2_RAT (1-217): 6.71e-76: 229: 100.00		NTRK1_RAT (58-839): 1.52e-171: 517: 47.78
+	Hs
		609244 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		FGFR3_HUMAN (140-838): 3.83e-170: 514: 23.73
+	Hs
		601492 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		FGFR2_HUMAN (203-838): 1.97e-168: 510: 24.89
+	Hs
		507939 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		FGFR1_HUMAN (162-838): 5.94e-163: 496: 23.43
+	Hs
		607935 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		FGFR4_HUMAN (166-837): 6.43e-152: 466: 24.57
+	Hs
		434170 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		RET_HUMAN (282-837): 1.5e-108: 360: 25.76
+	Hs
		924606 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		DDR2_HUMAN (527-824): 2.05e-70: 250: 43.30
+	Hs
		924517 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		DDR1_HUMAN (535-824): 9.4e-68: 244: 43.63
+	Hs
		924486 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		ROR2_HUMAN (522-828): 2.97e-67: 243: 41.56
+	Hs
		411352 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		INSR_HUMAN (513-824): 1.34e-64: 238: 39.43
+	Hs
		435602 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		IGF1R_HUMAN (513-820): 3.56e-64: 236: 39.16
+	Hs
		537729 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		INSRR_HUMAN (513-820): 1.33e-62: 231: 40.84
+	Hs
		924949 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		ALK_HUMAN (513-816): 2.78e-59: 222: 39.03
+	Hs
		994689 VAV3_HUMAN (1-212): 1.16e-43: 157: 22.00		DDR1_HUMAN (535-824): 9.4e-68: 244: 43.63
+	Hs
		411523 VAV3_HUMAN (1-212): 1.16e-43: 157: 22.00		INSR_HUMAN (513-824): 1.34e-64: 238: 39.43
+	Hs
		435801 VAV3_HUMAN (1-212): 1.16e-43: 157: 22.00		IGF1R_HUMAN (513-820): 3.56e-64: 236: 39.16
+	Hs
		411679 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		ROR2_HUMAN (522-828): 2.97e-67: 243: 41.56
+	Hs
		1356638 VAV3_HUMAN (1-212): 1.16e-43: 157: 22.00		ALK_HUMAN (513-816): 2.78e-59: 222: 39.03