HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: NTRK2 (Q16620)
BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (GP145-TrkB) (Trk-B) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Tropomyosin-related kinase B)
Gene: NTRK2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	LRR_8~SH2, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 822
+	Hs
		924601 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		NTRK3_HUMAN (13-822): 1.98e-178: 536: 52.84
+	Hs
		607935 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		FGFR4_HUMAN (152-820): 3.01e-178: 534: 24.68
+	Rn
		728442 GRB2_RAT (1-217): 6.71e-76: 229: 100.00		NTRK1_RAT (45-822): 7.98e-173: 520: 47.85
+	Hs
		609244 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		FGFR3_HUMAN (128-822): 1.4e-170: 514: 24.45
+	Hs
		384619 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Hs
		507939 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		FGFR1_HUMAN (180-821): 3.75e-164: 498: 23.77
+	Hs
		601492 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		FGFR2_HUMAN (120-821): 4.81e-164: 498: 23.04
+	Hs
		665389 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		EPHA3_HUMAN (82-821): 1.09e-157: 486: 21.32
+	Hs
		872610 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		EPHB1_HUMAN (149-822): 1.29e-142: 447: 23.00
+	Hs
		665200 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		EPHA2_HUMAN (148-822): 4.29e-141: 443: 22.43
+	Hs
		434170 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		RET_HUMAN (436-820): 1.09e-115: 379: 33.00
+	Hs
		924517 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		DDR1_HUMAN (535-807): 1.28e-74: 263: 47.37
+	Hs
		924606 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		DDR2_HUMAN (491-807): 5.97e-75: 263: 43.40
+	Hs
		435602 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		IGF1R_HUMAN (513-797): 1.01e-70: 256: 43.95
+	Hs
		411352 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		INSR_HUMAN (513-809): 2.11e-70: 254: 43.38
+	Hs
		924486 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		ROR2_HUMAN (530-808): 1.44e-69: 249: 44.52
+	Hs
		537729 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		INSRR_HUMAN (513-814): 4.91e-68: 247: 42.43
+	Hs
		924949 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		ALK_HUMAN (513-799): 4.96e-64: 236: 41.44
+	Hs
		666572 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		LTK_HUMAN (506-808): 6.29e-61: 223: 38.07
+	Hs
		411523 VAV3_HUMAN (1-212): 1.16e-43: 157: 22.00		INSR_HUMAN (513-809): 2.11e-70: 254: 43.38