HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: DDR2 (Q16832)
Discoidin domain-containing receptor 2 (Discoidin domain receptor 2) (EC 2.7.10.1) (CD167 antigen-like family member B) (Discoidin domain-containing receptor tyrosine kinase 2) (Neurotrophic tyrosine kinase, receptor-related 3) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO10) (CD antigen CD167b)
Gene: DDR2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.646

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 855
+	Hs
		924517 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		DDR1_HUMAN (22-849): 0: 655: 52.08
+	Hs
		924603 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		NTRK2_HUMAN (498-850): 2.17e-106: 348: 40.50
+	Rn
		728442 GRB2_RAT (1-217): 6.71e-76: 229: 100.00		NTRK1_RAT (551-850): 7.16e-103: 338: 42.95
+	Hs
		507939 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		FGFR1_HUMAN (505-851): 2.72e-102: 337: 32.49
+	Hs
		601492 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		FGFR2_HUMAN (522-851): 6.41e-102: 336: 34.42
+	Dm
		993198 GRAP_DROME (1-215): 5.1e-62: 194: 62.79		CAD96_DROME (368-849): 2.12e-115: 371: 27.83
+	Hs
		384619 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		NTRK1_HUMAN (551-850): 5.06e-101: 333: 42.62
+	Hs
		609244 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		FGFR3_HUMAN (485-851): 5.88e-101: 333: 31.28
+	Hs
		924601 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		NTRK3_HUMAN (551-849): 3.61e-99: 329: 42.63
+	Hs
		607935 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		FGFR4_HUMAN (537-849): 4.35e-98: 325: 34.78
+	Mm
		763393 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		FYN_MOUSE (548-850): 1.33e-98: 319: 35.64
+	Hs
		522887 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SRC_HUMAN (521-850): 1.38e-97: 316: 31.52
+	Hs
		435602 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		IGF1R_HUMAN (535-845): 9.34e-58: 217: 40.13
+	Hs
		411352 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		INSR_HUMAN (511-849): 1.55e-55: 210: 37.76
+	Hs
		924486 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		ROR2_HUMAN (551-854): 8.47e-56: 209: 38.39
+	Hs
		337418 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		ABL1_HUMAN (557-846): 9.71e-55: 207: 41.03
+	Hs
		665389 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		EPHA3_HUMAN (554-845): 1.09e-54: 206: 38.93
+	Hs
		69206 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		A9UF07_HUMAN (557-846): 4.25e-54: 206: 41.03
+	Hs
		337466 GRAP_HUMAN (1-213): 2.32e-66: 205: 56.74		ABL1_HUMAN (557-846): 9.71e-55: 207: 41.03
+	Hs
		411523 VAV3_HUMAN (1-212): 1.16e-43: 157: 22.00		INSR_HUMAN (511-849): 1.55e-55: 210: 37.76